PhellamurinCAS# 52589-11-4 |
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| Cas No. | 52589-11-4 | SDF | Download SDF |
| PubChem ID | 193876 | Appearance | Powder |
| Formula | C26H30O11 | M.Wt | 518.5 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2R,3R)-3,5-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydrochromen-4-one | ||
| SMILES | CC(=CCC1=C(C=C(C2=C1OC(C(C2=O)O)C3=CC=C(C=C3)O)O)OC4C(C(C(C(O4)CO)O)O)O)C | ||
| Standard InChIKey | GRDZTDZJQRPNCN-YIANMRPHSA-N | ||
| Standard InChI | InChI=1S/C26H30O11/c1-11(2)3-8-14-16(35-26-23(34)21(32)19(30)17(10-27)36-26)9-15(29)18-20(31)22(33)24(37-25(14)18)12-4-6-13(28)7-5-12/h3-7,9,17,19,21-24,26-30,32-34H,8,10H2,1-2H3/t17-,19-,21+,22+,23-,24-,26-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The barks of Phellodendron chinense Schneid.
| Description | 1. Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided. |
| Targets | P-gp |
Phellamurin Dilution Calculator
Phellamurin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.9286 mL | 9.6432 mL | 19.2864 mL | 38.5728 mL | 48.216 mL |
| 5 mM | 0.3857 mL | 1.9286 mL | 3.8573 mL | 7.7146 mL | 9.6432 mL |
| 10 mM | 0.1929 mL | 0.9643 mL | 1.9286 mL | 3.8573 mL | 4.8216 mL |
| 50 mM | 0.0386 mL | 0.1929 mL | 0.3857 mL | 0.7715 mL | 0.9643 mL |
| 100 mM | 0.0193 mL | 0.0964 mL | 0.1929 mL | 0.3857 mL | 0.4822 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Marked decrease of cyclosporin absorption caused by phellamurin in rats.[Pubmed:11859464]
Planta Med. 2002 Feb;68(2):138-41.
Phellamurin is a flavonoid glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). In vitro everted rat intestine study indicated that Phellamurin inhibited intestinal P-glycoprotein in a dose-dependent manner. In order to investigate the effect of Phellamurin on cyclosporin absorption and disposition, rats were given cyclosporin (5 mg/kg) with or without Phellamurin in a parallel design. Fluorescence polarization immunoassay was used to determine the blood concentration of cyclosporin. Unanticipatedly, our results indicated that the coadministration of Phellamurin significantly decreased the Cmax of cyclosporin by 77 % and reduced the AUC(0-infinity) of cyclosporin by 56 %. This indicated that a serious interaction occurred between Phellamurin with cyclosporin. To ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.
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