PrunetinosideCAS# 89595-66-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 89595-66-4 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C22H22O10 | M.Wt | 446.41 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Prunetinoside Dilution Calculator
Prunetinoside Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2401 mL | 11.2005 mL | 22.4009 mL | 44.8019 mL | 56.0023 mL |
| 5 mM | 0.448 mL | 2.2401 mL | 4.4802 mL | 8.9604 mL | 11.2005 mL |
| 10 mM | 0.224 mL | 1.12 mL | 2.2401 mL | 4.4802 mL | 5.6002 mL |
| 50 mM | 0.0448 mL | 0.224 mL | 0.448 mL | 0.896 mL | 1.12 mL |
| 100 mM | 0.0224 mL | 0.112 mL | 0.224 mL | 0.448 mL | 0.56 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Prunetinoside Inhibits Lipopolysaccharide-Provoked Inflammatory Response via Suppressing NF-kappaB and Activating the JNK-Mediated Signaling Pathway in RAW264.7 Macrophage Cells.[Pubmed:35628252]
Int J Mol Sci. 2022 May 13;23(10):5442.
Inflammation is a multifaceted response of the immune system at the site of injury or infection caused by pathogens or stress via immune cells. Due to the adverse effects of chemical drugs, plant-based compounds are gaining interest in current research. Prunetinoside or prunetin-5-O-glucoside (PUG) is a plant-based active compound, which possesses anti-inflammatory effects on immune cells. In this study, we investigate the effect of PUG on mouse macrophage RAW264.7 cells with or without stimulation of lipopolysaccharide (LPS). Cytotoxicity results showed that PUG is non-cytotoxic to the cells and it reversed the cytotoxicity in LPS-stimulated cells. The levels of nitric oxide (NO) and interleukin-6 (IL-6) were determined using a NO detection kit and IL-6 ELISA kit, respectively, and showed a significant decrease in NO and IL-6 in PUG-treated cells. Western blot and qRT-PCR were performed for the expression of two important pro-inflammatory cytokines, COX2 and iNOS, and found that their expression was downregulated in a dose-dependent manner. Other pro-inflammatory cytokines, such as IL-1beta, IL-6, and TNFalpha, had reduced mRNA expression after PUG treatment. Furthermore, a Western blot was performed to calculate the expression of NF-kappaB and MAPK pathway proteins. The results show that PUG administration dramatically reduced the phosphorylation of p-Ikappabalpha, p-NF-kappaB 65, and p-JNK. Remarkably, after PUG treatment, p-P38 and p-ERK remain unchanged. Furthermore, docking studies revealed that PUG is covalently linked to NF-kappaB and suppresses inflammation. In conclusion, PUG exerted the anti-inflammatory mechanism by barring the NF-kappaB pathway and activating JNK. Thus, Prunetinoside could be adopted as a therapeutic compound for inflammatory-related conditions.
Phenolic constituents from the twigs of Betula schmidtii collected in Goesan, Korea.[Pubmed:31437665]
Phytochemistry. 2019 Nov;167:112085.
Six undescribed phenolic derivatives along with thirty two known compounds were isolated from the twigs of Betula schmidtii. The chemical structures were characterized through extensive spectroscopic analysis and chemical methods. All known compounds were first isolated in this plant. The anti-inflammatory effect of the isolates was tested by measuring nitric oxide production in lipopolysaccharide-activated BV-2 cells. Isotachioside, 4-allyl-2-hydrophenyl 1-O-beta-D-apiosyl-(1 --> 6)-beta-D-glucopyranoside, genistein 5-O-beta-D-glucoside, and Prunetinoside showed a slight potency to lower the NO production against LPS-activated microglia with IC(50) values of 23.9, 25.3, 28.8, and 34.0 muM, respectively.
