Rauvovertine ACAS# 2055073-75-9 |
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| Cas No. | 2055073-75-9 | SDF | Download SDF |
| PubChem ID | 134714911 | Appearance | Powder |
| Formula | C19H22N2O3 | M.Wt | 326.38 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,13S,15S,19R,20R,21R)-19-methyl-18-oxa-1,11-diazahexacyclo[11.8.0.02,16.04,12.05,10.015,20]henicosa-4(12),5,7,9-tetraene-17,21-diol | ||
| SMILES | CC1C2C3CC4C5=C(CC(C3C(O1)O)N4C2O)C6=CC=CC=C6N5 | ||
| Standard InChIKey | AWYNNQCKGSFTMD-UXCCTWNPSA-N | ||
| Standard InChI | InChI=1S/C19H22N2O3/c1-8-15-11-7-14-17-10(9-4-2-3-5-12(9)20-17)6-13(21(14)18(15)22)16(11)19(23)24-8/h2-5,8,11,13-16,18-20,22-23H,6-7H2,1H3/t8-,11+,13+,14+,15+,16?,18-,19?/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The stems of Rauvolfia verticillata.
| Description | 1. Rauvovertine A shows cytotoxicity in vitro against human tumor cell lines. |
Rauvovertine A Dilution Calculator
Rauvovertine A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0639 mL | 15.3196 mL | 30.6391 mL | 61.2783 mL | 76.5978 mL |
| 5 mM | 0.6128 mL | 3.0639 mL | 6.1278 mL | 12.2557 mL | 15.3196 mL |
| 10 mM | 0.3064 mL | 1.532 mL | 3.0639 mL | 6.1278 mL | 7.6598 mL |
| 50 mM | 0.0613 mL | 0.3064 mL | 0.6128 mL | 1.2256 mL | 1.532 mL |
| 100 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.6128 mL | 0.766 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Hexacyclic monoterpenoid indole alkaloids from Rauvolfia verticillata.[Pubmed:26474672]
Fitoterapia. 2015 Dec;107:44-48.
Five new hexacyclic monoterpenoid indole alkaloids, Rauvovertine A (1), 17-epi-Rauvovertine A (2), rauvovertine B (3), 17-epi-rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution. The structures of 1-5 were established by spectroscopic analysis and with the aid of molecular modeling. The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.
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