Rosavin

Anti-fatigue effects of rosavin extracted from Rhodiola rosea L.[Reference: WebLink]

Science & Technology of Food Industry, 2013, 34(6):357-9.

To study the anti-fatigue effects of Rosavin extracted from Rhodiola rosea L. in mice.
METHODS AND RESULTS:
The mice were randomly divided into five groups including the control group administered with physiological saline,three Rosavin groups administered with doses of 60,180,360mg/kg mb Rosavin and salidroside group(180mg/kg mb) for 30 consecutive days,respectively. And the level of muscle lactate,liver and muscle glycogen,serum urea nitrogen and the exhaustive swimming time were determined after swimming test. Results:Compared with control group,different doses of Rosavin significantly extended the swimming time(p0.05) and increased the contents of liver(p0.05)and muscle glycogen,while reducing that of lactate in muscle significantly(p0.05). Salidroside was slightly better than Rosavin in the anti-fatigue effects of the same dose. But there was no significant difference in Rosavin and salidroside(p0.05).
CONCLUSIONS:
Rosavin had anti-fatigue effect on mice.

The influence of Rhodiola rosea extracts and rosavin on cutaneous angiogenesis induced in mice after grafting of syngeneic tumor cells[Reference: WebLink]

Central-European Journal of Immunology, 2008, 33(3):102-7.

Anticancer research on the plant species Rhodiola rosea L. (Crassulaceae) has begun in animal models in 1987. In combination with cyclophosphamide, R. rosea extract enhanced the anti-tumor and anti-metastatic effects of drug treatment and reduced drug-induced toxicity. Combined with Adriamycin®, it improved inhibition of tumor dissemination and prevented liver toxicity.
METHODS AND RESULTS:
The aim of the present work was to study the effect of Rosavin and aqueous and 50% hydroalcoholic extracts of R. rosea roots and rhizomes on neovascular reaction induced in the skin of Balb/c mice after grafting of L-1 sarcoma cells. Mice were treated per os with 50, 100, 200 and 400 μg of extracts, or were fed Rosavin in daily doses 2, 4 and 8 μg. After 72 hours mice were sacrificed with lethal dose of Morbital. All newly formed blood vessels were identified and counted in dissection microscope. Both extracts in 100-400 μg daily doses and Rosavin in the highest dose highly significantly decreased neovascular reaction.

Biotechnol Lett. 2014 Mar;36(3):649-56.

Biotransformation of cinnamyl alcohol to rosavins by non-transformed wild type and hairy root cultures of Rhodiola kirilowii.[Pubmed: 24190481]

Non-transformed wild type (NTWT) and hairy root cultures of Rhodiola kirilowii were grown in medium supplemented with 2.5 mM cinnamyl alcohol as a precursor and/or sucrose (1 %) on the day of inoculation or on the 14th day of culture. Rosarin, Rosavin, and rosin were produced by NTWT root culture but only rosarin and Rosavin by hairy roots. Approximately 80 and 95 % of the glycosides were released into the medium for NTWT and hairy root cultures, respectively. The highest Rosavin yield, 505 ± 106 mg/l, was in hairy root culture when cinnamyl alcohol was applied on the day of inoculation with the addition of sucrose on the 14th day of culture. For rosin production, supplementation with cinnamyl alcohol alone on day 14 was more favourable with the highest amount 74 ± 10 mg/l in NTWT root culture. Only traces of rosarin were detected.