Rubroside H

CAS# 227597-43-5

Rubroside H

Catalog No. BCN1857----Order now to get a substantial discount!

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Quality Control of Rubroside H

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Chemical structure

Rubroside H

3D structure

Chemical Properties of Rubroside H

Cas No. 227597-43-5 SDF Download SDF
PubChem ID 134715041 Appearance Red powder
Formula C31H35Cl3N2O9 M.Wt 685.98
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-[(2S,4Z)-4-[(2E,4E,6E,8E,10Z,12E,14Z)-11,15-dichloro-15-[(3S,5R)-3-chloro-5-methyloxolan-2-yl]-1-hydroxypentadeca-2,4,6,8,10,12,14-heptaenylidene]-3,5-dioxo-1-[(2R,4R,5R)-3,4,5-trihydroxyoxan-2-yl]pyrrolidin-2-yl]acetamide
SMILES CC1CC(C(O1)C(=CC=CC(=CC=CC=CC=CC=CC(=C2C(=O)C(N(C2=O)C3C(C(C(CO3)O)O)O)CC(=O)N)O)Cl)Cl)Cl
Standard InChIKey BJDOLCBECYAJRD-REQCGARRSA-N
Standard InChI InChI=1S/C31H35Cl3N2O9/c1-17-14-20(34)29(45-17)19(33)12-9-11-18(32)10-7-5-3-2-4-6-8-13-22(37)25-26(40)21(15-24(35)39)36(30(25)43)31-28(42)27(41)23(38)16-44-31/h2-13,17,20-21,23,27-29,31,37-38,41-42H,14-16H2,1H3,(H2,35,39)/b3-2+,6-4+,7-5+,11-9+,13-8+,18-10-,19-12-,25-22-/t17-,20+,21+,23-,27-,28?,29?,31-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Rubroside H

Description1. Rubroside H may show antifungal activity against Aspergillus fumigatus and Candida albicans.
TargetsAntifection

Rubroside H Dilution Calculator

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Rubroside H Molarity Calculator

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Preparing Stock Solutions of Rubroside H

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.4578 mL 7.2888 mL 14.5777 mL 29.1554 mL 36.4442 mL
5 mM 0.2916 mL 1.4578 mL 2.9155 mL 5.8311 mL 7.2888 mL
10 mM 0.1458 mL 0.7289 mL 1.4578 mL 2.9155 mL 3.6444 mL
50 mM 0.0292 mL 0.1458 mL 0.2916 mL 0.5831 mL 0.7289 mL
100 mM 0.0146 mL 0.0729 mL 0.1458 mL 0.2916 mL 0.3644 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Rubroside H

Rubrosides A−H, New Bioactive Tetramic Acid Glycosides from the Marine Sponge Siliquariaspongia japonica1

J. Org. Chem., 1999, 64 (7):2331–9.

Eight new tetramic acid glycosides named rubrosides A-H(rubroside A,rubroside B, rubroside C, rubroside D, rubroside E, rubroside F, Rubroside G, Rubroside H) have been isolated from the marine sponge Siliquariaspongia japonica. Their structures were elucidated on the basis of spectral data as tetramic acid glycosides containing polyenes terminating in a 4-chloro-2-methyltetrahydrofuran ring. The absolute stereochemistry of the furan functionality in the two major metabolites, rubrosides D and F, was determined by the NMR method using chiral anisotropic reagents for tetrahydro-2-furoic acid derived by RuO4 oxidation. The absolute stereochemistry of tetramic acid and of the sugar moieties in all rubrosides was deduced by chiral GC analysis of chemical degradation products. The rubrosides induced numerous large intracellular vacuoles in 3Y1 rat fibroblasts at concentrations of 0.5−1.0 μg/mL, and rubrosides A, C, D, and E were cytotoxic against P388 murine leukemia cells with IC50 values of 0.046−0.21 μg/mL. Most rubrosides show antifungal activity against Aspergillus fumigatus and Candida albicans.

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