Rutarin

Herbal Medicine and Voice Quality: Uncovering the Impact Through Acoustic Analysis.[Pubmed:39551657]

J Voice. 2024 Nov 16:S0892-1997(24)00377-1.

OBJECTIVE: Rutarin, an herbal formulation combining powdered seeds of Cydonia oblonga (quince) and aerial parts of Origanum majorana (marjoram), is used to address respiratory issues and enhance voice quality. This study investigates the effects of Rutarin on voice parameters, including fundamental frequency (F0), jitter, shimmer, harmonics-to-noise ratio (HNR), cepstral peak prominence (CPP), and smoothed cepstral peak prominence (CPPS). METHODS: Voice samples of 79 individuals who produced a sustained vowel /a/ were examined before and after consuming either Rutarin or warm water. The pretest vowel production was performed twice with a 5-minute interval between the first and second recordings before the actual test. Following consumption, the post test was performed five times for each participant at intervals immediately after drinking, 5, 15, 35, and 60 minutes. The repeated measure analysis of variance and Friedman test were employed to assess the within-subject differences, allowing the analysis of multiple conditions experienced by the same individual. RESULTS: Despite the recognized medicinal properties of its components, Rutarin did not produce significant improvements in voice quality compared to water. Water demonstrated notable effects on F0, jitter, HNR, CPP, and CPPS, particularly in male participants (P < 0.05). CONCLUSION: Although Rutarin may offer some therapeutic advantages for throat and respiratory health, it does not appear to enhance vocal performance as claimed.

Metabolome profile variations in common bean (Phaseolus vulgaris L.) resistant and susceptible genotypes incited by rust (Uromyces appendiculatus).[Pubmed:37007949]

Front Genet. 2023 Mar 16;14:1141201.

The causal agent of rust, Uromyces appendiculatus is a major constraint for common bean (Phaseolus vulgaris) production. This pathogen causes substantial yield losses in many common bean production areas worldwide. U. appendiculatus is widely distributed and although there have been numerous breakthroughs in breeding for resistance, its ability to mutate and evolve still poses a major threat to common bean production. An understanding of plant phytochemical properties can aid in accelerating breeding for rust resistance. In this study, metabolome profiles of two common bean genotypes Teebus-RR-1 (resistant) and Golden Gate Wax (susceptible) were investigated for their response to U. appendiculatus races (1 and 3) at 14- and 21-days post-infection (dpi) using liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-qTOF-MS). Non-targeted data analysis revealed 71 known metabolites that were putatively annotated, and a total of 33 were statistically significant. Key metabolites including flavonoids, terpenoids, alkaloids and lipids were found to be incited by rust infections in both genotypes. Resistant genotype as compared to the susceptible genotype differentially enriched metabolites including aconifine, D-sucrose, galangin, Rutarin and others as a defence mechanism against the rust pathogen. The results suggest that timely response to pathogen attack by signalling the production of specific metabolites can be used as a strategy to understand plant defence. This is the first study to illustrate the utilization of metabolomics to understand the interaction of common bean with rust.

[Chemical constituents from roots of Peucedanum praeruptorum (V)].[Pubmed:23477142]

Zhongguo Zhong Yao Za Zhi. 2012 Dec;37(23):3573-6.

OBJECTIVE: To study the chemical constituents in roots of Peucedanum praeruptorum from Henan. METHOD: The constituents were isolated by column chromatography on silica gel and ODS, and identified by NMR, MS spectroscopic methods. RESULT: Six compounds, Pd-I b(1), marmesinsin (2), Rutarin (3), isoRutarin (4), 4H-1-benzopyran-4-one, 5-hydroxy-6-methoxy-2-phenyl-7-O-alpha-D-glucuronyl methyl ester (5), 4H-1-benzopyran-4-one, 5-hydroxy-6-methoxy-2-phenyl-7-O-alpha-D-glucuronyl acid (6) were isolated and identified. CONCLUSION: Compound 5 was a new compound, compounds 5 and 6 were isolated from Peucedanum plant for the first time.

Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark.[Pubmed:21985060]

J Nat Prod. 2011 Oct 28;74(10):2286-9.

From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (Rutarin (3), seselin (4), suberosin (5), demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7alpha-obacunyl acetate (11). The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 mug/mL.

Structures of linear furano- and simple-coumarin glycosides of Bai-Hua Qian-Hu.[Pubmed:17262257]

Planta Med. 1989 Feb;55(1):64-7.

From the n-butanol extract of the crude drug "Bai-Hua Qian-Hu", the root of PEUCEDANUM PRAERUPTORUM Dunn. (Umbelliferae) praeroside I ( 1) and three known linear-type furanocoumarin glycosides, isoRutarin ( 2), Rutarin ( 3), and marmesinin ( 4), along with two known simple coumarin glycosides, scopolin ( 5) and skimmin ( 6), were isolated. The structure of praeroside I was established as rutaretin-4'- O-(6-vanilloyl-beta- D-glucopyranoside) by spectroscopic and chemical methods.