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Salicyl alcohol

CAS# 90-01-7

Salicyl alcohol

Catalog No. BCN4442----Order now to get a substantial discount!

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Quality Control of Salicyl alcohol

Number of papers citing our products

Chemical structure

Salicyl alcohol

3D structure

Chemical Properties of Salicyl alcohol

Cas No. 90-01-7 SDF Download SDF
PubChem ID 5146 Appearance Powder
Formula C7H8O2 M.Wt 124.1
Type of Compound Phenols Storage Desiccate at -20°C
Synonyms 2-Hydroxybenzyl alcohol; Saligenin
Solubility DMSO : ≥ 100 mg/mL (805.54 mM)
H2O : 33.33 mg/mL (268.49 mM; Need ultrasonic)
*"≥" means soluble, but saturation unknown.
Chemical Name 2-(hydroxymethyl)phenol
SMILES C1=CC=C(C(=C1)CO)O
Standard InChIKey CQRYARSYNCAZFO-UHFFFAOYSA-N
Standard InChI InChI=1S/C7H8O2/c8-5-6-3-1-2-4-7(6)9/h1-4,8-9H,5H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Salicyl alcohol

The herbs of Myrica rubra

Biological Activity of Salicyl alcohol

DescriptionBenzyl and salicyl alcohol, the local anesthetics, are effective inhibitors of lymphocyte-mediated cytolysis (LMC) in vitro.
In vitro

Inhibition of lymphocyte-mediated cytolysis by the local anesthetics benzyl and salicyl alcohol[Reference: WebLink]

European Journal of Immunology ,2010 ,3 (11) :674-7.

The local anesthetics, benzyl and Salicyl alcohol, are effective inhibitors of lymphocyte-mediated cytolysis (LMC) in vitro.
METHODS AND RESULTS:
LMC is not inhibited when the cytotoxic lymphocytes or target cells are preincubated in drug concentrations which are inhibitory if present during the reaction. Analysis of the cytolytic reaction has indicated that the inhibition of LMC is due to an interference with the interaction of lymphocytes and target cells, rather than suppression of the lytic phase of the reaction. Investigation of the effect on LMC of a number of different compounds with local anesthetic properties has shown that they inhibit LMC when present in similar concentrations to those known to block nerve impulse conduction.
CONCLUSIONS:
It is suggested that reversible cell membrane disorganization produced by these substances is the means whereby LMC is inhibited.

In vivo

Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates.[Pubmed: 24292286]

Naunyn Schmiedebergs Arch Pharmacol. 2014 Mar;387(3):281-90.

The present study was conducted to synthesize nitrogen containing derivatives of Salicyl alcohol and to investigate in vivo their ulcerogenic potential in comparison with aspirin in rats.
METHODS AND RESULTS:
The compounds [4-(2-hydroxybenzyl) morpholin-4-iumchloride (I)] and [1,4-bis(2-hydroxybenzyl) piperazine-1,4-diium chloride (II)] were synthesized and their chemical structures were characterized using spectral data. In our previous study (Ali et al., Afr J Pharm Pharmacol 7:585-596, 2013), both compounds showed anti-inflammatory, antinociceptive, and antipyretic properties in standard animal models and a greater binding affinity for cyclooxygenase-2 versus cyclooxygenase-1 in molecular docking and dynamics analysis. For in vivo studies, animals were randomly divided into four groups. The synthetic compounds (both at 100 or 150 mg/kg), aspirin (150 mg/kg), or saline vehicle was administered orally, once daily for 6 days and then tested for ulcerogenic activity. At the end of the procedure, gastric juice and tissues were collected and subjected to biochemical and histological analyses. The results of the study revealed that in the case of the aspirin-treated group, there was a significant increase in gastric juice volume, free acidity, total acidity, and ulcer score and a decrease in gastric pH. Moreover, histological examination of the gastric mucosa of the aspirin-treated group indicated morphological changes while neither of the synthetic compounds showed any significant ulcerogenic or cytotoxic properties.
CONCLUSIONS:
The results of the present study suggest that both compounds are free from ulcerogenic side effects and may represent a better alternative to aspirin.

Protocol of Salicyl alcohol

Animal Research

Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study.[Pubmed: 24085627]

Arch Pharm Res. 2014 Jul;37(7):916-26.

The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of Salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats.
METHODS AND RESULTS:
The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II).
CONCLUSIONS:
This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.

Salicyl alcohol Dilution Calculator

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Salicyl alcohol Molarity Calculator

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Preparing Stock Solutions of Salicyl alcohol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 8.058 mL 40.2901 mL 80.5802 mL 161.1604 mL 201.4504 mL
5 mM 1.6116 mL 8.058 mL 16.116 mL 32.2321 mL 40.2901 mL
10 mM 0.8058 mL 4.029 mL 8.058 mL 16.116 mL 20.145 mL
50 mM 0.1612 mL 0.8058 mL 1.6116 mL 3.2232 mL 4.029 mL
100 mM 0.0806 mL 0.4029 mL 0.8058 mL 1.6116 mL 2.0145 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Salicyl alcohol

Salicyl alcohol is an intermediate for medicine, perfume, pesticide.

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References on Salicyl alcohol

Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study.[Pubmed:24085627]

Arch Pharm Res. 2014 Jul;37(7):916-26.

The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of Salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.

Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates.[Pubmed:24292286]

Naunyn Schmiedebergs Arch Pharmacol. 2014 Mar;387(3):281-90.

The present study was conducted to synthesize nitrogen containing derivatives of Salicyl alcohol and to investigate in vivo their ulcerogenic potential in comparison with aspirin in rats. The compounds [4-(2-hydroxybenzyl) morpholin-4-iumchloride (I)] and [1,4-bis(2-hydroxybenzyl) piperazine-1,4-diium chloride (II)] were synthesized and their chemical structures were characterized using spectral data. In our previous study (Ali et al., Afr J Pharm Pharmacol 7:585-596, 2013), both compounds showed anti-inflammatory, antinociceptive, and antipyretic properties in standard animal models and a greater binding affinity for cyclooxygenase-2 versus cyclooxygenase-1 in molecular docking and dynamics analysis. For in vivo studies, animals were randomly divided into four groups. The synthetic compounds (both at 100 or 150 mg/kg), aspirin (150 mg/kg), or saline vehicle was administered orally, once daily for 6 days and then tested for ulcerogenic activity. At the end of the procedure, gastric juice and tissues were collected and subjected to biochemical and histological analyses. The results of the study revealed that in the case of the aspirin-treated group, there was a significant increase in gastric juice volume, free acidity, total acidity, and ulcer score and a decrease in gastric pH. Moreover, histological examination of the gastric mucosa of the aspirin-treated group indicated morphological changes while neither of the synthetic compounds showed any significant ulcerogenic or cytotoxic properties. The results of the present study suggest that both compounds are free from ulcerogenic side effects and may represent a better alternative to aspirin.

Description

Salicyl alcohol is an intermediate for medicine, perfume, pesticide.

Keywords:

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