Lobelin

[Effect of cholinergic substances on nociceptive evoked responses in specific thalamic nuclei].[Pubmed:7439367]

Farmakol Toksikol. 1980 Jul-Aug;43(4):360-3.

The effect of the M-cholinomimetic arecoline and M-cholinolytic metamizil, n-cholinomimetic Lobelin and n-cholinolytic -506 (beta-ethylenespasmolytin) on the formation of nociceptive responses induced by dental pulp stimulation was studied by means of microinjections into the rabbit thalamus preparations VPM and VPL. Arecoline and -506 decreased while metamizil and Lobelin increased the amplitude of the primary responses. No changes in the latent periods were noted. It is concluded that the activation of the M-cholinergic structures of specific nuclei of the thalamus reduces the nociceptive responses. The activation of the N-cholinergic structures potentiates the nociceptive responses in specific relays.

[Case report of collagen lung in SLE presenting with cough variant asthma: relation between the localization of responsible receptors and cough].[Pubmed:1569725]

Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Mar;30(3):453-7.

A 27-year-old nonsmoking woman complained of cough and chest oppression for two years since an episode of pneumonia. Clinical tests showed decrease in FEV1.0 during attacks of coughing and evidence of bronchial hypersensitivity. While these events fitted the picture of bronchial asthma, the nonwheezing cough suggested cough variant asthma. Antinuclear antibody and anti-ds DNA antibody were increased and leukopenia was recognized, suggesting the diagnosis of systemic lupus erythematosus (SLE). Bronchoalveolar lavage showed lymphocytic alveolitis and decreased T4/T8. These results were suggestive of collagen lung induced by SLE. Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the induction of coughing. We conclude that the peripheral lesion of collagen lung stimulates the peripheral c-fiber receptors, leading to cough variant asthma.

The variability and repeatability of indices derived from the single-breath diagram for CO2 in horses with chronic obstructive pulmonary disease and the effect of lobelin hydrochloride on these indices.[Pubmed:11469511]

Vet Res Commun. 2001 Jul;25(5):401-12.

Several indices of ventilatory heterogeneity can be identified from the volumetric capnogram and its graphic presentation, the single-breath diagram for CO2 (SBD-CO2). Physiologically based indices of pulmonary function (VTE, VCO2, FACO2, VDBohr% VDBohr%, VD/VTE, A1/A2) were calculated for healthy horses (group I, n = 5) and for horses with subclinical (group II, n = 7) or clinically manifest chronic obstructive pulmonary disease (COPD) (group III, n = 8) during tidal breathing and after medication with Lobelin hydrochloride (Lobelin). We investigated the variability and repeatability of the lung function indices in healthy horses and in those with COPD both during tidal breathing and after administration of Lobelin, a centrally acting respiratory stimulant. In particular, we were interested in whether the discriminating ability of SBD-CO2-derived lung function indices would be increased between different patient groups after administration of Lobelin compared to those for the resting values. Of the indices studied, VTE, FACO, VDBohr% and A1/A2 appeared to be those with good to excellent repeatability in discriminating healthy horses from those with COPD. Stimulating respiration with Lobelin gave no advantage in the repeatability of the lung function indices or in differentiating between horses with different degrees of COPD.