Scandenolide

CAS# 23758-16-9

Scandenolide

Catalog No. BCN9432----Order now to get a substantial discount!

Product Name & Size Price Stock
Scandenolide: 5mg $989 In Stock
Scandenolide: 10mg Please Inquire In Stock
Scandenolide: 20mg Please Inquire Please Inquire
Scandenolide: 50mg Please Inquire Please Inquire
Scandenolide: 100mg Please Inquire Please Inquire
Scandenolide: 200mg Please Inquire Please Inquire
Scandenolide: 500mg Please Inquire Please Inquire
Scandenolide: 1000mg Please Inquire Please Inquire

Quality Control of Scandenolide

Number of papers citing our products

Chemical structure

Scandenolide

3D structure

Chemical Properties of Scandenolide

Cas No. 23758-16-9 SDF Download SDF
PubChem ID 98927 Appearance Powder
Formula C17H18O7 M.Wt 334.3
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (8-methyl-3-methylidene-4,14-dioxo-5,9,15-trioxatetracyclo[11.2.1.02,6.08,10]hexadec-13(16)-en-12-yl) acetate
SMILES CC(=O)OC1CC2C(O2)(CC3C(C4C=C1C(=O)O4)C(=C)C(=O)O3)C
Standard InChIKey SLIMCFUYVZKJTC-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H18O7/c1-7-14-11-4-9(16(20)22-11)10(21-8(2)18)5-13-17(3,24-13)6-12(14)23-15(7)19/h4,10-14H,1,5-6H2,2-3H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Scandenolide Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Scandenolide Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Scandenolide

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9913 mL 14.9566 mL 29.9133 mL 59.8265 mL 74.7831 mL
5 mM 0.5983 mL 2.9913 mL 5.9827 mL 11.9653 mL 14.9566 mL
10 mM 0.2991 mL 1.4957 mL 2.9913 mL 5.9827 mL 7.4783 mL
50 mM 0.0598 mL 0.2991 mL 0.5983 mL 1.1965 mL 1.4957 mL
100 mM 0.0299 mL 0.1496 mL 0.2991 mL 0.5983 mL 0.7478 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Scandenolide

Assessment of sesquiterpene lactones isolated from Mikania plants species for their potential efficacy against Trypanosoma cruzi and Leishmania sp.[Pubmed:28945741]

PLoS Negl Trop Dis. 2017 Sep 25;11(9):e0005929.

Four sesquiterpene lactones, mikanolide, deoxymikanolide, dihydromikanolide and Scandenolide, were isolated by a bioassay-guided fractionation of Mikania variifolia and Mikania micrantha dichloromethane extracts. Mikanolide and deoxymikanolide were the major compounds in both extracts (2.2% and 0.4% for Mikania variifolia and 21.0% and 6.4% for Mikania micrantha respectively, calculated on extract dry weight). Mikanolide, deoxymikanolide and dihydromikanolide were active against Trypanosoma cruzi epimastigotes (50% inhibitory concentrations of 0.7, 0.08 and 2.5 mug/mL, for each compound respectively). These sesquiterpene lactones were also active against the bloodstream trypomastigotes (50% inhibitory concentrations for each compound were 2.1, 1.5 and 0.3 mug/mL, respectively) and against amastigotes (50% inhibitory concentrations for each compound were 4.5, 6.3 and 8.5 mug/mL, respectively). By contrast, Scandenolide was not active on Trypanosoma cruzi. Besides, mikanolide and deoxymikanolide were also active on Leishmania braziliensis promastigotes (50% inhibitory concentrations of 5.1 and 11.5 mug/mL, respectively). The four sesquiterpene lactones were tested for their cytotoxicity on THP 1 cells. Deoxymikanolide presented the highest selectivity index for trypomastigotes (SI = 54) and amastigotes (SI = 12.5). In an in vivo model of Trypanosoma cruzi infection, deoxymikanolide was able to decrease the parasitemia and the weight loss associated to the acute phase of the parasite infection. More importantly, while 100% of control mice died by day 22 after receiving a lethal T. cruzi infection, 70% of deoxymikanolide-treated mice survived. We also observed that this compound increased TNF-alpha and IL-12 production by macrophages, which could contribute to control T. cruzi infection.

Antimicrobial constituents of the leaves of Mikania micrantha H. B. K.[Pubmed:24098556]

PLoS One. 2013 Oct 2;8(10):e76725.

BACKGROUND: To isolate plant-derived compounds with antimicrobial activity from the leaves of Mikania micrantha, to determine the compounds configuration, and to evaluate their antimicrobial activity against eight plant pathogenic fungi (Exserohilum turcicum, Colletotrichum lagenarium, Pseudoperonispora cubensis, Botrytis cirerea, Rhizoctonia solani, Phytophthora parasitica, Fusarium solani, and Pythium aphanidermatum,) and four plant pathogenic bacteria (gram negative bacteria: Ralstonia dolaanacearum, Xanthomonas oryzae pv. Oryzae, Xanthomonas Campestris pv. Vesicatoria, and Xanthomonas campestris pv. Citri), and four bacteria (gram positive bacteria: Staphyloccocus aureus, Bacillus subtilis, Micrococcus luteus, and Bacillus cereus). METHODS AND RESULTS: Antimicrobial constituents of the leaves of M. micrantha were isolated using bioactivity- guided fractionation. The antifungal activity of the isolated compounds was evaluated by the inhibit hypha growth method and inhibit spore germination method. Characterization of antibacterial activity was carried out using the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs). MIC and MBC were determined by the broth microdilution method. Six compounds - deoxymikanolide, Scandenolide, dihydroScandenolide, mikanolide, dihydromikanolide, and m - methoxy benzoic acid - have been isolated from leaves of Mikania micrantha H. B. K. Deoxymikanolide, Scandenolide, and dihydroScandenolide were new compounds. The result of bioassay showed that all of isolated compounds were effective against tested strains and deoxymikanolide showed the strongest activity. CONCLUSIONS AND SIGNIFICANCE: The leaves of M. micrantha may be a promising source in the search for new antimicrobial drugs due to its efficacy and the broadest range. Meanwhile, adverse impact of M. micrantha will be eliminated.

Analgesic sesquiterpene dilactone from Mikania cordata.[Pubmed:11731117]

Fitoterapia. 2001 Dec;72(8):919-21.

The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and Scandenolide, did not show significant analgesic activity.

Inhibition of leukotriene and platelet activating factor synthesis in leukocytes by the sesquiterpene lactone scandenolide.[Pubmed:2168055]

Planta Med. 1990 Jun;56(3):268-70.

The sesquiterpene lactone Scandenolide, isolated from the Philippines medicinal plant Mikania cordata, at a dose of 100 microM completely inhibited whole blood chemiluminescence in response to the activators PMA and zymosan. In isolated inflammatory rat leukocytes this compound inhibited both leukotriene B4 and 5-HETE production with IC50 of 15 microM and 30 microM, respectively. The formation of the cyclooxygenase product thromboxane B2 was not inhibited in the concentration range 10 to 200 microM of Scandenolide. The formation of the potent inflammatory mediator platelet activating factor (PAF) was suppressed by microM concentrations of Scandenolide with an IC50 of less than 20 microM. The presence of a compound in M. cordata which inhibits some of the inflammatory mediators such as leukotrienes and PAF may explain at least in part some of its medicinal properties.

Keywords:

Scandenolide,23758-16-9,Natural Products, buy Scandenolide , Scandenolide supplier , purchase Scandenolide , Scandenolide cost , Scandenolide manufacturer , order Scandenolide , high purity Scandenolide

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: