Schisanlactone A

CAS# 87164-31-6

Schisanlactone A

Catalog No. BCN3185----Order now to get a substantial discount!

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Quality Control of Schisanlactone A

Number of papers citing our products

Chemical structure

Schisanlactone A

3D structure

Chemical Properties of Schisanlactone A

Cas No. 87164-31-6 SDF Download SDF
PubChem ID 102004778 Appearance Powder
Formula C30H40O4 M.Wt 464.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=CCC(OC1=O)C(C)C2CCC3(C2(CCC4=C3CCC5C(=C4)C=CC(=O)OC5(C)C)C)C
Standard InChIKey VJNOAOVMGNCSPJ-MBPMSANUSA-N
Standard InChI InChI=1S/C30H40O4/c1-18-7-11-25(33-27(18)32)19(2)22-14-16-30(6)24-10-9-23-20(8-12-26(31)34-28(23,3)4)17-21(24)13-15-29(22,30)5/h7-8,12,17,19,22-23,25H,9-11,13-16H2,1-6H3/t19?,22-,23-,25?,29-,30+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Schisanlactone A

The herbs of Kadsura longipedunculata Finet.et Gagnep

Biological Activity of Schisanlactone A

Description1. Schisanlactone A shows cytotoxicity against KB (a human epidermal carcinoma) cells with the IC50 value of 63.3 uM. 2. Schisanlactone A is a dimerization inhibitor, with an IC50 value of 5.0 microg/mL. 3. Schisanlactone A shows appreciable inhibitory activity against HIV-1 protease with the IC50 value of 20 microM.
TargetsHIV

Schisanlactone A Dilution Calculator

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Schisanlactone A Molarity Calculator

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Preparing Stock Solutions of Schisanlactone A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1519 mL 10.7596 mL 21.5193 mL 43.0385 mL 53.7981 mL
5 mM 0.4304 mL 2.1519 mL 4.3039 mL 8.6077 mL 10.7596 mL
10 mM 0.2152 mL 1.076 mL 2.1519 mL 4.3039 mL 5.3798 mL
50 mM 0.043 mL 0.2152 mL 0.4304 mL 0.8608 mL 1.076 mL
100 mM 0.0215 mL 0.1076 mL 0.2152 mL 0.4304 mL 0.538 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Schisanlactone A

Cattienoids A-C, three novel steroids from the mushroom Tomophagus cattienensis.[Pubmed:24001711]

Fitoterapia. 2013 Dec;91:125-127.

Three novel steroids (1-3), named cattienoids A-C together with Schisanlactone A (4), were isolated from fruiting bodies of Tomophagus cattienensis (Ganodermataceae)-a new mushroom recently collected from Cattien National Park, in Viet Nam. They possess an unusual seven membered lactone ring, derived from lanostane-type triterpenoids. Their structures were determined by spectroscopic methods. In addition, compounds 2 and 4 showed cytotoxicity against KB (a human epidermal carcinoma) cells with their IC50 values of 91.2 and 63.3 muM, respectively. These compounds have neither antimicrobial activity nor inhibition of the tyrosinase.

Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease.[Pubmed:16394567]

Chem Pharm Bull (Tokyo). 2006 Jan;54(1):129-32.

Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and Schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 microM, respectively.

Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum.[Pubmed:19813754]

J Nat Prod. 2009 Nov;72(11):2019-23.

A new farnesyl hydroquinone, ganomycin I (1), was isolated along with ganomycin B (2) from the chloroform extract of the fruiting bodies of the Vietnamese mushroom Ganoderma colossum. These compounds inhibited HIV-1 protease with IC50 values of 7.5 and 1.0 microg/mL, respectively. Kinetic studies using Zhang-Poorman and Lineweaver plots revealed that compound 2 competitively inhibited the active site of the enzyme, whereas the tetracyclic triterpene Schisanlactone A, previously isolated from the same fungus, was a dimerization inhibitor, with an IC50 value of 5.0 microg/mL. The previous findings were also confirmed by the virtual docking of both compounds with HIV-1 protease crystal structure.

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