Senecionine N-oxideCAS# 13268-67-2 |
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| Cas No. | 13268-67-2 | SDF | Download SDF |
| PubChem ID | 5380876 | Appearance | White powder |
| Formula | C18H25NO6 | M.Wt | 351.17 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in methanol; sparingly soluble in ethyl acetate | ||
| SMILES | CC=C1CC(C(C(=O)OCC2=CC[N+]3(C2C(CC3)OC1=O)[O-])(C)O)C | ||
| Standard InChIKey | PLGBHVNNYDZWGZ-GPUZEBNTSA-N | ||
| Standard InChI | InChI=1S/C18H25NO6/c1-4-12-9-11(2)18(3,22)17(21)24-10-13-5-7-19(23)8-6-14(15(13)19)25-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4-/t11-,14-,15-,18-,19?/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
1 Caltha sp. 2 Crotalaria sp. 3 Emilia sp. 4 Gynura sp. 5 Petasites sp. 6 Senecio sp. 7 Tussilago sp.
| Description | 1.Senecionine N-oxide and senecionine have hepatotoxic activity, no antifertility effects in MeOH extract-treated hamsters. |
Senecionine N-oxide Dilution Calculator
Senecionine N-oxide Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8476 mL | 14.2381 mL | 28.4762 mL | 56.9525 mL | 71.1906 mL |
| 5 mM | 0.5695 mL | 2.8476 mL | 5.6952 mL | 11.3905 mL | 14.2381 mL |
| 10 mM | 0.2848 mL | 1.4238 mL | 2.8476 mL | 5.6952 mL | 7.1191 mL |
| 50 mM | 0.057 mL | 0.2848 mL | 0.5695 mL | 1.139 mL | 1.4238 mL |
| 100 mM | 0.0285 mL | 0.1424 mL | 0.2848 mL | 0.5695 mL | 0.7119 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris.[Pubmed:3411472]
J Pharm Sci. 1988 May;77(5):461-3.
The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1-10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and Senecionine N-oxide, suggesting that the latter two compounds were probably responsible for the effect seen with the extract. No antifertility effects were seen in MeOH extract-treated hamsters.
Differing embryotoxic effects of senecionine and senecionine-N-oxide on the chick embryo.[Pubmed:7873804]
Funct Dev Morphol. 1994;4(2):89-92.
The embryotoxic properties of pyrrolizidine alkaloids senecionine (water insoluble) and senecionine-N-oxide (water soluble) were examined using the CHEST method (Chick Embryotoxicity Screening Test). The beginning of the embryotoxicity range for senecionine was found to be between 3-30 micrograms; senecionine-N-oxide, on the other hand, showed no effect even with 100 micrograms dose. On the basis of the theoretical calculation, it can be expected that senecionine embryotoxicity for mammals ranges between 10-100 mg/kg maternal body weight, overlapping in this way the known adult toxicity range. The rat LD50 of most alkaloids known to be significant for human health are in the range of 34-300 mg/kg.
Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity.
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