Soladulcoside ACAS# 137031-53-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
| Cas No. | 137031-53-9 | SDF | Download SDF |
| PubChem ID | N/A | Appearance | Powder |
| Formula | C39H62O15 | M.Wt | 770.9 |
| Type of Compound | Steroid Saponins and its Sapogenins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Soladulcoside A Dilution Calculator
Soladulcoside A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.2972 mL | 6.4859 mL | 12.9719 mL | 25.9437 mL | 32.4296 mL |
| 5 mM | 0.2594 mL | 1.2972 mL | 2.5944 mL | 5.1887 mL | 6.4859 mL |
| 10 mM | 0.1297 mL | 0.6486 mL | 1.2972 mL | 2.5944 mL | 3.243 mL |
| 50 mM | 0.0259 mL | 0.1297 mL | 0.2594 mL | 0.5189 mL | 0.6486 mL |
| 100 mM | 0.013 mL | 0.0649 mL | 0.1297 mL | 0.2594 mL | 0.3243 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells.[Pubmed:30643798]
Biomed Res Int. 2018 Dec 16;2018:3120972.
Degalactotigonin (1) and three other steroidal compounds solasodine (2), O-acetyl solasodine (3), and Soladulcoside A (4) were isolated from the methanolic extract of Solanum nigrum, and their chemical structures were elucidated by spectroscopic analyses. The isolated compounds were evaluated for cytotoxic activity against human pancreatic cancer cell lines (PANC1 and MIA-PaCa2) and lung cancer cell lines (A549, NCI-H1975, and NCI-H1299). Only degalactotigonin (1) showed potent cytotoxicity against these cancer cell lines. Compound 1 induced apoptosis in PANC1 and A549 cells. Further study on its mechanism of action in PANC1 cells demonstrated that 1 significantly inhibited EGF-induced proliferation and migration in a concentration-dependent manner. Treatment of PANC1 cells with degalactotigonin induced cell cycle arrest at G0/G1 phase. Compound 1 induced downregulation of cyclin D1 and upregulation of p21 in a time- and concentration-dependent manner and inhibited EGF-induced phosphorylation of EGFR, as well as activation of EGFR downstream signaling molecules such as Akt and ERK.
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