(+)-SophoridineCAS# 83148-91-8 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 83148-91-8 | SDF | Download SDF |
| PubChem ID | 285698 | Appearance | Powder |
| Formula | C15H24N2O | M.Wt | 248.4 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | (+)-Matrine;Matridin-15-one;Allomatrine | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | None | ||
| SMILES | C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1 | ||
| Standard InChIKey | ZSBXGIUJOOQZMP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
(+)-Sophoridine Dilution Calculator
(+)-Sophoridine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0258 mL | 20.1288 mL | 40.2576 mL | 80.5153 mL | 100.6441 mL |
| 5 mM | 0.8052 mL | 4.0258 mL | 8.0515 mL | 16.1031 mL | 20.1288 mL |
| 10 mM | 0.4026 mL | 2.0129 mL | 4.0258 mL | 8.0515 mL | 10.0644 mL |
| 50 mM | 0.0805 mL | 0.4026 mL | 0.8052 mL | 1.6103 mL | 2.0129 mL |
| 100 mM | 0.0403 mL | 0.2013 mL | 0.4026 mL | 0.8052 mL | 1.0064 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antiviral activity of sophoridine against enterovirus 71 in vitro.[Pubmed:30853644]
J Ethnopharmacol. 2019 May 23;236:124-128.
ETHNOPHARMACOLOGICAL RELEVANCE: Enterovirus 71 (EV71) has a propensity to cause hand-foot-and-mouth disease (HFMD) epidemics associated with neurological sequelae. Unfortunately, no drugs are currently available for the clinical treatment of EV71 infections. Sophoridine (SRI) is one of the most abundant alkaloids in Sophora flavescens Aiton (Leguminosae), which has been used to treat fever, throat inflammation, cancer, and other diseases. MATERIALS AND METHODS: In this study, we found that SRI inhibits EV71 infection in Vero cells. To study the antiviral activity of SRI, Vero cells were divided into 3 treatment groups based on the timing of SRI dosing: prior to viral adsorption (Group A), during viral adsorption (Group B), and after viral adsorption (Group C). We further revealed the antiviral activity of SRI with the attachment assay and the penetration assay. For Group A, 50% viability of Vero cells was observed at a SRI concentration of 61.39mug/mL, whereas for Groups B, 50% viability was observed at SRI concentrations of 196.86mug/mL. Furthermore, 29.7% cell viability was observed even at a SRI concentration of 1000mug/mL in Groups C. The results show that SRI was highly effective against EV71 when Vero cells were pretreated with SRI for 2h (Group A). Further researches indicate SRI was highly effective at inhibiting EV71 attachment when the SRI concentrations over 250mug/mL (P<0.001). CONCLUSIONS: We have shown that Vero cell viability increases when SRI is administered prior to viral adsorption. This suggests that SRI has the considerable potential as an antiviral for EV71 disease prevention.
