TCFHCAS# 94790-35-9 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 94790-35-9 | SDF | Download SDF |
| PubChem ID | 4455752 | Appearance | Powder |
| Formula | C5H12CIF6N2P | M.Wt | 384.0 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in water or 1% acetic acid | ||
| Chemical Name | [chloro(dimethylamino)methylidene]-dimethylazanium | ||
| SMILES | CN(C)C(=[N+](C)C)Cl | ||
| Standard InChIKey | QZFWNEASXBNLCD-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C5H12ClN2/c1-7(2)5(6)8(3)4/h1-4H3/q+1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
TCFH Dilution Calculator
TCFH Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6042 mL | 13.0208 mL | 26.0417 mL | 52.0833 mL | 65.1042 mL |
| 5 mM | 0.5208 mL | 2.6042 mL | 5.2083 mL | 10.4167 mL | 13.0208 mL |
| 10 mM | 0.2604 mL | 1.3021 mL | 2.6042 mL | 5.2083 mL | 6.5104 mL |
| 50 mM | 0.0521 mL | 0.2604 mL | 0.5208 mL | 1.0417 mL | 1.3021 mL |
| 100 mM | 0.026 mL | 0.1302 mL | 0.2604 mL | 0.5208 mL | 0.651 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate (TCFH), a powerful coupling reagent for bioconjugation.[Pubmed:18803415]
Bioconjug Chem. 2008 Oct;19(10):1968-71.
Prodrugs are increasingly used as delivery vehicles for pharmaceutical agents that present solubility and/or pharmacokinetic/metabolic issues. In the course of the development of prodrugs for the antitumoral agent thiocoraline, standard coupling reagents and procedures failed to provide the desired target derivatives because of the lack of reactivity of its quinolinic alcohol. In contrast, the use of N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate (TCFH) resulted in good yields of ester prodrugs of thiocoraline and could be applicable to other drugs with similar limitations.
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