2beta-(Isobutyryloxy)florilenalinCAS# 94898-78-9 |
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| Cas No. | 94898-78-9 | SDF | Download SDF |
| PubChem ID | 57404511 | Appearance | Powder |
| Formula | C19H26O5 | M.Wt | 334.41 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(3aR,5aS,6S,8R,8aR,9aR)-8-hydroxy-8-methyl-1,5-dimethylidene-2-oxo-3a,4,5a,6,7,8a,9,9a-octahydroazuleno[6,5-b]furan-6-yl] 2-methylpropanoate | ||
| SMILES | CC(C)C(=O)OC1CC(C2C1C(=C)CC3C(C2)C(=C)C(=O)O3)(C)O | ||
| Standard InChIKey | RPFZMZXPFLBITO-UGRJFSIRSA-N | ||
| Standard InChI | InChI=1S/C19H26O5/c1-9(2)17(20)24-15-8-19(5,22)13-7-12-11(4)18(21)23-14(12)6-10(3)16(13)15/h9,12-16,22H,3-4,6-8H2,1-2,5H3/t12-,13-,14-,15+,16-,19-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Centipeda minima
| Description | 1. 2beta-(Isobutyryloxy)florilenalin induces apoptosis in human nasopharyngeal carcinoma CNE cells. |
| Targets | Bcl-2/Bax | Caspase | PARP | P450 (e.g. CYP17) |
2beta-(Isobutyryloxy)florilenalin Dilution Calculator
2beta-(Isobutyryloxy)florilenalin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9903 mL | 14.9517 mL | 29.9034 mL | 59.8068 mL | 74.7585 mL |
| 5 mM | 0.5981 mL | 2.9903 mL | 5.9807 mL | 11.9614 mL | 14.9517 mL |
| 10 mM | 0.299 mL | 1.4952 mL | 2.9903 mL | 5.9807 mL | 7.4759 mL |
| 50 mM | 0.0598 mL | 0.299 mL | 0.5981 mL | 1.1961 mL | 1.4952 mL |
| 100 mM | 0.0299 mL | 0.1495 mL | 0.299 mL | 0.5981 mL | 0.7476 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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2beta-(Isobutyryloxy)florilenalin, a sesquiterpene lactone isolated from the medicinal plant Centipeda minima, induces apoptosis in human nasopharyngeal carcinoma CNE cells.[Pubmed:19553887]
Molecules. 2009 Jun 12;14(6):2135-46.
Centipeda minima is a medicinal plant reputed in China as a remedy for nasopharyngeal carcinoma (NPC). In this study, bioactivity-guided fractionation of the anti-NPC compound(s) from C. minima led to the isolation of 2beta-(Isobutyryloxy)florilenalin (IF), a sesquiterpene lactone. IF showed significant dose- and time- dependent inhibition on the growth of the human nasopharyngeal carcinoma epithelia cells (CNE). It induced apoptosis in CNE cells, as shown by the accumulation of sub-G1 cell population, DNA fragmentation and nuclear condensation, caspase-3 activation and PARP cleavage. Such induction was associated with the depletion of mitochondrial membrane potential (DeltaPsim) and the release of cytochrome c to cytosol to regulate the expression of Bcl-2 family proteins. These activities led to the cleavage of caspases and the trigger of cell death process. Overall, IF in C. minima showed potent antiproliferative effect of C. minima on NPC cells, suggesting that the plant deserves more extensive investigation for its potential medicinal application.
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