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6-Methoxynaringenin

CAS# 94942-49-1

6-Methoxynaringenin

Catalog No. BCN4500----Order now to get a substantial discount!

Product Name & Size Price Stock
6-Methoxynaringenin: 5mg $725 In Stock
6-Methoxynaringenin: 10mg Please Inquire In Stock
6-Methoxynaringenin: 20mg Please Inquire Please Inquire
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6-Methoxynaringenin: 200mg Please Inquire Please Inquire
6-Methoxynaringenin: 500mg Please Inquire Please Inquire
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Quality Control of 6-Methoxynaringenin

Number of papers citing our products

Chemical structure

6-Methoxynaringenin

3D structure

Chemical Properties of 6-Methoxynaringenin

Cas No. 94942-49-1 SDF Download SDF
PubChem ID 5322074 Appearance Powder
Formula C16H14O6 M.Wt 302.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-2,3-dihydrochromen-4-one
SMILES COC1=C(C=C2C(=C1O)C(=O)CC(O2)C3=CC=C(C=C3)O)O
Standard InChIKey FCXRFTLSXMRXTM-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 6-Methoxynaringenin

The herbs of Humulus lupulus

Biological Activity of 6-Methoxynaringenin

Description6-Methoxynaringenin is a natural product from Salvia plebeia.

Protocol of 6-Methoxynaringenin

Structure Identification
Natural Product Sciences , 2010 , 16 (4) :207-210.

Phytochemical constituents from Salvia plebeia.[Reference: WebLink]


METHODS AND RESULTS:
Phytochemical investigation of Salvia plebeia resulted in the isolation of nine compounds. Their structures were determined to be 6-Methoxynaringenin (1), 6-Methoxynaringenin-7-O-β-D-glucoside (2), hispidulin (3), homoplantaginin (4), nepetin (5), nepitrin (6), 6-hydroxyluteolin (7), caffeic acid (8) and rosmarinic acid (9) by spectroscopic analyses.
CONCLUSIONS:
6-Methoxynaringenin (1), 6-hydroxyluteolin (7) and rosmarinic acid (9) were isolated from this plant for the first time.

6-Methoxynaringenin Dilution Calculator

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6-Methoxynaringenin Molarity Calculator

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Preparing Stock Solutions of 6-Methoxynaringenin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.308 mL 16.5399 mL 33.0797 mL 66.1594 mL 82.6993 mL
5 mM 0.6616 mL 3.308 mL 6.6159 mL 13.2319 mL 16.5399 mL
10 mM 0.3308 mL 1.654 mL 3.308 mL 6.6159 mL 8.2699 mL
50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3232 mL 1.654 mL
100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.6616 mL 0.827 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 6-Methoxynaringenin

Phenolics and eudesmanolide from aged common sage exudate with sugar.[Pubmed:30263686]

Food Sci Biotechnol. 2017 Dec 12;26(6):1491-1500.

Nineteen compounds including one new flavanone were isolated from the juice of aged common sage exudate with sugar (ACSE). The isolated compounds were identified by NMR and MS analyses as levodopa methyl ester (1), 3,4-dihydroxybenzoic acid (2), (S)-8-hydroxy-4-hydroxy-phenylpropanoic acid (3), 4-hydroxybenzoic acid ethyl ester (4), cis-caffeic acid (5), trans-caffeic acid (6), esculetin (7), (S)-8-hydroxy-3,4-dihydroxy-phenylpropanoic acid ethyl ester (8), cis-rosmarinic acid (9), trans-rosmarinic acid (10), trans-rosmarinic acid methyl ester (11), 6-methoxy-7,8,3',5'-tetrahydroxyflavanone (12), nepetin (13), trans-caffeic acid ethyl ester (14), luteolin (15), cis-caffeic acid ethyl ester (16), 6-Methoxynaringenin (17), 1alpha-acetoxy-2-oxo-eudesman-3,7(11)-dien-8beta,12-olide (18), and hispidulin (19). Compound 12 was isolated for the first time from nature and seven compounds (1, 3, 4, 7, 8, 14, and 18) were newly identified from common sage. Of them, 15 isolated phenolic compounds (1-3, 5-8, 10-15, 17, and 19) were detected in ACSE juice, while only 10 was detected in the fresh common sage.

Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS-Stimulated Microglial Cells.[Pubmed:28805952]

Chem Biodivers. 2017 Nov;14(11).

The arial parts of Scutellaria barbata D. Don (Lamiaceae) efficiently inhibited NO production in BV2 microglial cells, and the active constituents were further isolated based on activity-guided isolation using silica-gel column chromatography, RP-C18 MPLC and prep-HPLC. As the results, 2 flavonoids including 6-Methoxynaringenin (1) and 6-O-methylscutellarein (5), and 6 neo-clerodane diterpenes such as scutebarbatine W (2), scutebatas B (3), scutebarbatine B (4), scutebarbatine A (6), 6-O-nicotinolylscutebarbatine G (7), and scutebarbatine X (8) were isolated. The structures of these compounds were elucidated based on NMR and MS data, and the comparison of literature values. All the compounds except compound 7 inhibited NO production efficiently with IC50 values of lower than 50 mum. Particularly, compounds 1 and 8 were the most efficient with IC50 values of 25.8 and 27.4 mum, respectively. This is the first report suggesting the potential of S. barbata on the reduction of neuroinflammation.

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