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7,3'-Dihydroxy-5'-methoxyisoflavone

CAS# 947611-61-2

7,3'-Dihydroxy-5'-methoxyisoflavone

Catalog No. BCN3349----Order now to get a substantial discount!

Product Name & Size Price Stock
7,3'-Dihydroxy-5'-methoxyisoflavone: 5mg Please Inquire In Stock
7,3'-Dihydroxy-5'-methoxyisoflavone: 10mg Please Inquire In Stock
7,3'-Dihydroxy-5'-methoxyisoflavone: 20mg Please Inquire Please Inquire
7,3'-Dihydroxy-5'-methoxyisoflavone: 50mg Please Inquire Please Inquire
7,3'-Dihydroxy-5'-methoxyisoflavone: 100mg Please Inquire Please Inquire
7,3'-Dihydroxy-5'-methoxyisoflavone: 200mg Please Inquire Please Inquire
7,3'-Dihydroxy-5'-methoxyisoflavone: 500mg Please Inquire Please Inquire
7,3'-Dihydroxy-5'-methoxyisoflavone: 1000mg Please Inquire Please Inquire

Quality Control of 7,3'-Dihydroxy-5'-methoxyisoflavone

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Chemical structure

7,3'-Dihydroxy-5'-methoxyisoflavone

3D structure

Chemical Properties of 7,3'-Dihydroxy-5'-methoxyisoflavone

Cas No. 947611-61-2 SDF Download SDF
PubChem ID 66728338 Appearance Yellow powder
Formula C16H12O5 M.Wt 284.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 7-hydroxy-3-(3-hydroxy-5-methoxyphenyl)chromen-4-one
SMILES COC1=CC(=CC(=C1)O)C2=COC3=C(C2=O)C=CC(=C3)O
Standard InChIKey CJAXVEMKKDGDQM-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7,3'-Dihydroxy-5'-methoxyisoflavone

The rhizomes of Polygonatum kingianum

Biological Activity of 7,3'-Dihydroxy-5'-methoxyisoflavone

Description1. 7,3'-Dihydroxy-5'-methoxyisoflavone shows moderate activity against the renal, melanoma and breast cancer cell lines. 2. 7,3'-Dihydroxy-5'-methoxyisoflavone may have a synergistic effect with other anticancer drugs.

7,3'-Dihydroxy-5'-methoxyisoflavone Dilution Calculator

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7,3'-Dihydroxy-5'-methoxyisoflavone Molarity Calculator

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Preparing Stock Solutions of 7,3'-Dihydroxy-5'-methoxyisoflavone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5174 mL 17.5871 mL 35.1741 mL 70.3482 mL 87.9353 mL
5 mM 0.7035 mL 3.5174 mL 7.0348 mL 14.0696 mL 17.5871 mL
10 mM 0.3517 mL 1.7587 mL 3.5174 mL 7.0348 mL 8.7935 mL
50 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.407 mL 1.7587 mL
100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.7035 mL 0.8794 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 7,3'-Dihydroxy-5'-methoxyisoflavone

Isoflavones from Calpurnia Aurea subsp. aurea and their anticancer activity.[Pubmed:25395701]

Afr J Tradit Complement Altern Med. 2014 Aug 23;11(5):33-7. eCollection 2014.

BACKGROUND: Calpurnia aurea is an African medicinal plant used in many countries in Africa to treat a range of medical conditions or disorders. Extracts of the plant were shown to be active in antibacterial and antioxidant assays as well as against lice, ticks and maggots. The aim of the study was to isolate the phytochemical constituents from the plant and to test them in appropriate bioassays dependent on the compounds isolated in order to provide a rationale for the use of the plant in ethno-medicine or to provide some information on its constituents. MATERIALS AND METHODS: The stem and bark of the plant was extracted with organic solvents of varying polarity and the extracts separated and purified using column chromatography. The isolated compounds were identified by NMR spectroscopy and the compounds were tested for their in vitro anticancer activity against breast (MCF7), renal (TK10) and melanoma (UACC62) human cell lines using an in house method developed at the CSIR, South Africa. RESULTS: The isoflavones, 4',5,7-trihydroxyisoflavone (1), 7,3'-dihydroxy-5'-methoxyisoflavone (2), 7-hydroxy-4',8-dimethoxyisoflavone (3), 7-acetoxy-4',8-dimethoxyisoflavone (4) and 3',7-dihydroxy-4',8-dimethoxyisoflavone (5), a pterocarpan (3-acetoxy-9-methoxypterocarpan) and a quinolizidine alkaloid (calpurnine) were isolated from the stem and bark of Calpurnia aurea. The tetrasubstituted isoflavone 5 was found to be the most active in the three cell lines amongst all the compounds tested. This was followed by trisubstituted isoflavone 2. CONCLUSION: The isoflavones showed moderate activity against the renal, melanoma and breast cancer cell lines tested against, with the isoflavones 2 and 5 showing the best activity of the compounds tested. These isoflavones may have a synergistic effect with other anticancer drugs.

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