Vulpic acid

CAS# 521-52-8

Vulpic acid

Catalog No. BCN6546----Order now to get a substantial discount!

Product Name & Size Price Stock
Vulpic acid: 5mg $219 In Stock
Vulpic acid: 10mg Please Inquire In Stock
Vulpic acid: 20mg Please Inquire Please Inquire
Vulpic acid: 50mg Please Inquire Please Inquire
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Quality Control of Vulpic acid

Number of papers citing our products

Chemical structure

Vulpic acid

3D structure

Chemical Properties of Vulpic acid

Cas No. 521-52-8 SDF Download SDF
PubChem ID 54690323 Appearance Powder
Formula C19H14O5 M.Wt 322.32
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl (2E)-2-(3-hydroxy-5-oxo-4-phenylfuran-2-ylidene)-2-phenylacetate
SMILES COC(=O)C(=C1C(=C(C(=O)O1)C2=CC=CC=C2)O)C3=CC=CC=C3
Standard InChIKey OMZRMXULWNMRAE-BMRADRMJSA-N
Standard InChI InChI=1S/C19H14O5/c1-23-18(21)15(13-10-6-3-7-11-13)17-16(20)14(19(22)24-17)12-8-4-2-5-9-12/h2-11,20H,1H3/b17-15+
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Vulpic acid

The lichen metabolites.

Biological Activity of Vulpic acid

Description1. Vulpic acid can inhibit one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for liver stage activity. 2. Vulpic acid has therapeutic and prophylactic potential to be antibacterial and antiplasmodial agents.
TargetsFatty Acid Synthase

Vulpic acid Dilution Calculator

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Vulpic acid Molarity Calculator

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Preparing Stock Solutions of Vulpic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1025 mL 15.5125 mL 31.0251 mL 62.0501 mL 77.5627 mL
5 mM 0.6205 mL 3.1025 mL 6.205 mL 12.41 mL 15.5125 mL
10 mM 0.3103 mL 1.5513 mL 3.1025 mL 6.205 mL 7.7563 mL
50 mM 0.0621 mL 0.3103 mL 0.6205 mL 1.241 mL 1.5513 mL
100 mM 0.031 mL 0.1551 mL 0.3103 mL 0.6205 mL 0.7756 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Vulpic acid

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.[Pubmed:23806111]

J Nat Prod. 2013 Jun 28;76(6):1064-70.

Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal prophylaxis of malaria. In this study, four lichen metabolites, evernic acid (1), Vulpic acid (2), psoromic acid (3), and (+)-usnic acid (4), were evaluated against LS parasites of Plasmodium berghei. Inhibition of P. falciparum blood stage (BS) parasites was also assessed to determine stage specificity. Compound 4 displayed the highest LS activity and stage specificity (LS IC50 value 2.3 muM, BS IC50 value 47.3 muM). The compounds 1-3 inhibited one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for LS activity. To determine species specificity and to clarify the mechanism of reported antibacterial effects, 1-4 were also evaluated against FabI homologues and whole cells of various pathogens (S. aureus, E. coli, M. tuberculosis). Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of the FAS-II enzymes. Potential toxicity of compounds was assessed in human hepatocyte and cancer cells (in vitro) as well as in a zebrafish model (in vivo). This study indicates the therapeutic and prophylactic potential of lichen metabolites as antibacterial and antiplasmodial agents.

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