Cancer Research

Cancer is a term used to define a group of diseases in which abnormal cells divide without control, are able to invade neighboring tissues/organs and metastasize. Cancer has been characterized by six hallmarks; self sufficiency in proliferative growth signals, insensitivity to growth inhibitors, evasion of apoptosis, limitless replicative potential, ability to develop blood vessels (angiogenesis), and tissue invasion and metastasis.

Cancer Research Products Areas

Products for Cancer Research - Page 91

Cat.No. Product Name Information/Activity
BCC2554 PHT-427 PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 µM and 5.2 µM and for Akt and PDPK1, respectively.
BCC6160 SC 66 SC66 is an Akt inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.
BCC5748 Akt/SKG Substrate Peptide 276680-69-4
BCC5908 AKTide-2T 324029-01-8
BCC6246 SC 79 Akt activator,SC79 is a unique specific Akt activator that may be used to enhance Akt activity in various physiological and pathological conditions.
BCC1255 OSU-03012 (AR-12) PDPK1 (PDK1) inhibitor; inhibits Akt signaling,OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 μM in a cell-free assay and 2-fold increase in potency over OSU-02067.
BCC5745 SAMS Peptide SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).
BCC2080 A-769662 A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM.
BCC3606 AICAR AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR is also an autophagy and mitophagy inhibitor.
BCC4799 Metformin HCl Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy.