Cardiovascular System Research
The cardiovascular, or circulatory, system is a closed elastic circuit consisting of the heart, blood vessels (arteries, capillaries and veins) and the blood. The primary function is to pump oxygenated blood to the tissues throughout the body and reabsorb waste carbon dioxide for its removal. This function is performed by the use of pulmonary and systemic circulation.
Cardiovascular System Research Products Areas
Products for Cardiovascular System Research - Page 14
- Cat.No. Product Name Information/Activity
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BCC7654
L-798,106
L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM), it also has micromolar activities at the EP4, EP1 and EP2 receptors with Ki values of 916 nM, >5000 nM and >5000 nM at EP4, EP1 and EP2, respectively.
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BCC1822
ONO-AE3-208
High affinity and selective EP<sub>4</sub> antagonist,ONO-AE3-208 is an <b>EP4</b> antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.
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BCC6299
PF 04418948
PF-04418948 is an orally active, potent and selective prostaglandin EP2 receptor antagonist with an IC50 of 16 nM.
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BCC6968
SC 19220
19395-87-0
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BCC7773
SC 51089
146033-02-5
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BCC5941
SC 51322
146032-79-3
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BCN2215
Arachidonic acid
Arachidonic acid is an essential fatty acid and a major constituent of biomembranes.
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BCC3952
AC 264613
PAR<sub>2</sub> receptor agonist
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BCC3951
AC 55541
AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC50=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC50 values of 5.9 and 6.6 in PI hydrolysis assays and Ca2+ mobilization assays and exhibits pronociceptive activity in vivo.
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BCC3949
AY-NH2
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
