Nrf2
Nrf2 is a member of the basic leucine zipper family of transcription factors. Under normal physiological conditions, Nrf2 is degraded by the concerted actions of Keap1 and Cullin 3, yet during oxidative stress, Nrf2 promotes transcription of antioxidant genes.
Products for Nrf2
- Cat.No. Product Name Information/Activity
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BCC8018
AI-3
882288-28-0
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BCN5504
Curcumin
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities.
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BCC4776
Dimethyl Fumarate
Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression.
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BCC7941
MMF
Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease.
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BCC6295
TAT 14
1362661-34-4
