Integrin Receptor
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of α and β subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.
Products for Integrin Receptor
- Cat.No. Product Name Information/Activity
-
BCC3944
A 205804
A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases.
-
BCC3946
A 286982
Potent inhibitor of the LFA-1/ICAM-1 interaction
-
BCC3945
BIO 1211
Selective <span class='symbol'>α</span><sub>4</sub><span class='symbol'>β</span><sub>1</sub> (VLA-4) inhibitor
-
BCC8002
BIO 5192
327613-57-0
-
BCC3942
Cilengitide
Cilengitide, a cyclic RGD-containing peptide, is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50s of 4 and 79 nM, respectively.
-
BCC5988
Echistatin, α1 isoform
154303-05-6
-
BCC6998
GR 144053 trihydrochloride
1215333-48-4
-
BCC3943
MNS
MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases.
-
BCC6275
P11
848644-86-0
-
BCC7694
RGDS peptide
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function, decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9.
