Purinergic (P2X) Receptors
P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.
Products for Purinergic (P2X) Receptors - Page 3
- Cat.No. Product Name Information/Activity
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BCC6749
iso-PPADS tetrasodium salt
P2X antagonist
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BCC7015
PPNDS
1021868-77-8
-
BCC7276
Ro 0437626
134362-79-1
-
BCC6157
Ro 51
1050670-85-3
-
BCC7548
RO-3
1026582-88-6
-
BCC7079
Suramin hexasodium salt
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin sodium salt is an antitrypanosomal, anti-neoplastic and anti-angiogenic agent.
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BCC6155
TC-P 262
873398-67-5
-
BCC7373
TNP-ATP triethylammonium salt
61368-63-6
-
BCC4974
GW791343 HCl
GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
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BCC1251
Ivermectin
Ivermectin (MK-933) is a broad-spectrum anti-parasite medication used in humans most commonly to treat nematode infections such as onchocerciasis, as well as scabies and lice. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import.
