Voltage-gated Sodium (NaV) Channels
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear.
Products for Voltage-gated Sodium (NaV) Channels
- Cat.No. Product Name Information/Activity
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BCC7515
Veratridine
Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM.
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BCC5075
A-803467
A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.
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BCC7898
A 887826
A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC50 of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo.
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BCC5067
Ambroxol HCl
Na<sup>+</sup> channel blocker,AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
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BCC6294
APETx2
713544-47-9
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BCC4378
Carbamazepine
Carbamazepine, a sodium channel blocker, is an anticonvulsant drug.
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BCC7439
Co 102862
181144-66-1
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BCC1578
Flecainide acetate
Flecainide acetate (R-818) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
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BCC4398
Flunarizine 2HCl
Flunarizine is a selective calcium entry blocker.
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BCC6270
Huwentoxin IV
526224-73-7
