Respiratory Disease Research

The respiratory system consists of the lungs, airways, diaphragm, trachea (windpipe) and pharynx (throat) and its primary function is the exchange of oxygen and carbon dioxide- breathing in and out. Between 6 and 10 liters of air are brought in and out of the lungs and 0.3 liters of oxygen are transferred from the alveoli to the blood per minute.

Respiratory Disease Research Products Areas

Products for Respiratory Disease Research - Page 15

Cat.No. Product Name Information/Activity
BCC4104 GlyH-101 GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
BCC6711 NPPB NPPB is a blocker of the outwardly rectifying chloride channel (ORCC).
BCC5248 PPQ-102 PPQ-102 is a potent CFTR inhibitor which can completely inhibited CFTR chloride current with IC50 of ~90 nM.
BCC6220 T16Ainh - A01 T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).
BCC7391 Talniflumate 66898-62-2
BCC7578 KM 11060 KM11060 is a novel corrector of the F508del-CFTR trafficking defect.
BCC7820 PG 01 PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K
BCC7886 BTZO 1 BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.
BCC6816 Chicago Sky Blue 6B 2610-05-1
BCC6161 (±)-CPSI 1306 (±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).