Retinoic Acid Receptor
Retinoic acid receptors (RARs) are nuclear hormone receptors of the NR1B class, which function as heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes: RARα , present in most tissue types; and RARβ and RARγ , with more selective expression.
Products for Retinoic Acid Receptor - Page 2
- Cat.No. Product Name Information/Activity
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BCC2284
Isotretinoin
Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne.
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BCN2185
Retinoic acid
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM.
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BCC2540
Tazarotene
Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris.
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BCC4874
TTNPB (Arotinoid Acid)
TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
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BCC7740
BMS 195614
253310-42-8
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BCC7697
BMS 493
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation.
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BCC7778
CD 2665
CD2665 is a selective RAR-beta/gamma antagonist, with Ki values of 110 nM, 306 nM for RARγ and RARβ, respectively.
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BCC7783
ER 50891
187400-85-7
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BCC7782
MM 11253
345952-44-5
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BCC7679
BMS 453
166977-43-1
