MDM2 - Apoptosis - BioCrick

Cat.No. Product Name Information

BCC5648 MI-773 (SAR405838) SAR405838 is a highly potent and selective MDM2 inhibitor, binds to MDM2 with Ki= 0.88 nM and has high specificity over other proteins.

BCC5454 YH239-EE YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.

BCC2243 NSC 207895 (XI-006) NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.

BCC5503 Pifithrin-β Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.

BCC1156 Nutlin-3b Nutlin-3b is a p53/MDM2 inhibitor with an IC50 of 13.6 μM. Nutlin-3b is 150 times less potent in binding to MDM2 than Nutlin-3a.

BCC2255 NSC 66811 MDM2 inhibitor. Disrupts MDM2-p53 interaction

BCC1830 p53 and MDM2 proteins-interaction-inhibitor chiral p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins.

BCC1894 RG7112 RG7112 is a potent, selective, first clinical, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a KD of 11 nM for binding to MDM2. RG7112

BCC1831 p53 and MDM2 proteins-interaction-inhibitor racemic p53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins.

Products for MDM2