Products for FFAR1 (GPR40)
- Cat.No. Product Name Information
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BCC3702
TAK-875
Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
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BCC3786
GSK1292263
GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes.
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BCC4125
GPR40 Activator 1
GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.
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BCC2018
TUG-770
TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC50 of 6 nM for hFFA1.
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BCC1610
GW-1100
GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.
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BCC6387
AMG837
AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
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BCC1102
GW9508
GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities.
