BCC1780
MTEP hydrochloride
MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride produces antiparkinsonian-like effects.
BCC1745
mGlu2 agonist
LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants.
BCC1724
LY341495
LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.
BCC1777
MPEP Hydrochloride
MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.
BCC4595
VU 0357121
VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.
BCC3803
L-Glutamine
L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.
BCC1501
CPPHA
CPPHA is a selective positive allosteric modulator of mGluR5 receptor.
BCC5499
RG7090
Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
BCC4599
CTEP (RO4956371)
CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors.
BCC1531
Dipraglurant
Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.
BCC4594
MPEP
MPEP is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors.
