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beta-Amyrin palmitate

CAS# 5973-06-8

beta-Amyrin palmitate

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Quality Control of beta-Amyrin palmitate

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Chemical structure

beta-Amyrin palmitate

3D structure

Chemical Properties of beta-Amyrin palmitate

Cas No. 5973-06-8 SDF Download SDF
PubChem ID 165382 Appearance Powder
Formula C46H80O2 M.Wt 665.1
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(3S,6aR,6bS,8aR,12aS,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl] hexadecanoate
SMILES CCCCCCCCCCCCCCCC(=O)OC1CCC2(C(C1(C)C)CCC3(C2CC=C4C3(CCC5(C4CC(CC5)(C)C)C)C)C)C
Standard InChIKey VFSRKCNYYCXRGI-LAZBMHKSSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of beta-Amyrin palmitate

The root of Periploca sepium Bung.

Biological Activity of beta-Amyrin palmitate

Description1. Beta-Amyrin palmitate may release norepinephrine from newly synthesized pools, and thus, it may activate noradrenergic activity. 2. Beta-Amyrin palmitate, like mianserin and imipramine, reduces the duration of immobility of mice significantly in a dose-dependent manner (5, 10 and 20 mg kg-1); (1)Beta-Amyrin palmitate or mianserin elicits a dose-related reduction in locomotor activity of mice and antagonizes locomotor stimulation induced by methamphetamine, imipramine increases locomotor activity and potentiates methamphetamine-induced hyperactivity; (2)Beta-Amyrin palmitate shows no effect on reserpine-induced hypothermia, whilst mianserin (10 mg kg-1) and imipramine (10 and 20 mg kg-1) antagonizes the reserpine-induced effect; (3)Beta-amyrin palmitate has similar properties in some respects to mianserin and might possess a sedative action.
TargetsLDL | HMG-CoA Reductase | Adrenergic Receptor

beta-Amyrin palmitate Dilution Calculator

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beta-Amyrin palmitate Molarity Calculator

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Preparing Stock Solutions of beta-Amyrin palmitate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5035 mL 7.5177 mL 15.0353 mL 30.0707 mL 37.5883 mL
5 mM 0.3007 mL 1.5035 mL 3.0071 mL 6.0141 mL 7.5177 mL
10 mM 0.1504 mL 0.7518 mL 1.5035 mL 3.0071 mL 3.7588 mL
50 mM 0.0301 mL 0.1504 mL 0.3007 mL 0.6014 mL 0.7518 mL
100 mM 0.015 mL 0.0752 mL 0.1504 mL 0.3007 mL 0.3759 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on beta-Amyrin palmitate

A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test.[Pubmed:8423710]

Life Sci. 1993;52(3):289-96.

A mechanism of antidepressant activity of beta-Amyrin palmitate was studied using the forced swimming method in mice. beta-Amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyrosine (500 mg/kg). beta-Amyrin palmitate (5 and 10 mg/kg) decreased the duration of immobility in mice treated with desipramine plus 6-hydroxy-dopamine (50 micrograms/mouse), but did not affect that induced by nomifensine plus 6-hydroxydopamine. The decreased immobility produced by desipramine (15 mg/kg) was not affected by beta-Amyrin palmitate. A study of norepinephrine release in mouse brain synaptosomes indicated that beta-Amyrin palmitate caused a release of [3H]norepinephrine. The results of the present study suggest that beta-Amyrin palmitate might release norepinephrine from newly synthesized pools, and thus, it might activate noradrenergic activity.

Promising anti-diabetes mellitus activity in rats of beta-amyrin palmitate isolated from Hemidesmus indicus roots.[Pubmed:24726843]

Eur J Pharmacol. 2014 Jul 5;734:77-82.

While evaluating the toxicity of the tuberous root extracts of Hemidesmus indicus, a traditional medicinal plant, the glucose lowering property of the root was observed by the investigators. Therefore, it was thought of interest to isolate the anti-hyperglycemic principle from the root and determine its utility to develop an anti-diabetes mellitus medicine. The active principle was isolated from H. indicus root extract by anti-hyperglycemic activity guided chromatographic techniques. Glucose tolerance test in rats was used to evaluate the anti-hyperglycenic property. Anti-diabetes mellitus property was evaluated in alloxan-induced diabetic rats as well as streptozotocin-induced (type-2 model) diabetic rats. The active principle was isolated and identified with spectral data as beta-Amyrin palmitate. Although it is a known compound, its presence in H. indicus is not known previously. It was observed for the first time that beta-Amyrin palmitate has remarkable anti-hyperglycemic activity in orally glucose loaded rats. Further, interestingly, it exhibited excellent anti-diabetes mellitus activity in both alloxan-diabetic and streptozotocin-diabetic rats at a very low concentration (50microg/kg body weight). One of the mechanisms of action of beta-Amyrin palmitate appears to be blocking the entry of glucose from the intestine. beta-Amyrin palmitate is very promising to develop a medicine for diabetes for combination therapy and/or mono-therapy.

An alpha-adrenoceptor-mediated mechanism of hypoactivity induced by beta-amyrin palmitate.[Pubmed:7908030]

J Pharm Pharmacol. 1993 Nov;45(11):1006-8.

Inhibitory effects of beta-Amyrin palmitate in locomotor activity of mice were studied by combining this compound with alpha-adrenergic agonists or antagonists and a dopaminergic agonist. beta-Amyrin palmitate (2.5, 5.0 and 10.0 mg kg-1, i.p.) decreased locomotor activity of mice in a dose-dependent manner. It enhanced hypoactivity of mice treated with clonidine (0.025 mg kg-1, i.p.) and antagonized hyperactivity produced by phenylephrine (40 micrograms, i.c.v.). The inhibitory action of beta-Amyrin palmitate was not affected by yohimbine (1.5 mg kg-1, i.p.), but was potentiated by prazosin (0.75 mg kg-1, i.p.). When combined with a dopaminergic agonist, apomorphine (2.0 mg kg-1, i.p.), beta-Amyrin palmitate (5.0 and 10.0 mg kg-1, i.p.) did not affect locomotor stimulation produced by apomorphine. These results suggest that beta-Amyrin palmitate might inhibit alpha 1-adrenoceptors.

Pharmacological properties of beta-amyrin palmitate, a novel centrally acting compound, isolated from Lobelia inflata leaves.[Pubmed:8103103]

J Pharm Pharmacol. 1993 Jun;45(6):545-50.

Effects of beta-Amyrin palmitate isolated from the leaves of Lobelia inflata were studied on the central nervous system of mice and were compared with those of antidepressant drugs, mianserin and imipramine. In the forced swimming test, beta-Amyrin palmitate, like mianserin and imipramine, reduced the duration of immobility of mice significantly in a dose-dependent manner (5, 10 and 20 mg kg-1). beta-Amyrin palmitate (5, 10 and 20 mg kg-1) or mianserin (5, 10 and 20 mg kg-1) elicited a dose-related reduction in locomotor activity of mice and antagonized locomotor stimulation induced by methamphetamine. In contrast, imipramine (5, 10 and 20 mg kg-1) increased locomotor activity and potentiated methamphetamine-induced hyperactivity. beta-Amyrin palmitate showed no effect on reserpine-induced hypothermia, whilst mianserin (10 mg kg-1) and imipramine (10 and 20 mg kg-1) antagonized the reserpine-induced effect. Unlike imipramine, beta-Amyrin palmitate and mianserin did not affect haloperidol-induced catalepsy, tetrabenazine-induced ptosis and apomorphine-induced stereotypy. beta-Amyrin palmitate and imipramine had no effects on the head-twitch response induced by 5-hydroxytryptophan, whereas mianserin (5, 10 and 20 mg kg-1) decreased it in a dose-dependent manner. A potentiating effect of beta-Amyrin palmitate (5, 10 and 20 mg kg-1) on narcosis induced by sodium pentobarbitone was stronger than that of imipramine (10, 20 and 40 mg kg-1) but weaker than that of mianserin (2.5, 5 and 10 mg kg-1). These results suggest that beta-Amyrin palmitate has similar properties in some respects to mianserin and might possess a sedative action.(ABSTRACT TRUNCATED AT 250 WORDS)

beta-Amyrin acetate and beta-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves.[Pubmed:22541636]

Phytomedicine. 2012 Jun 15;19(8-9):682-5.

The ethanolic extract and fractions of Wrightia tomentosa Roem. & Schult (Apocynaceae) leaves were tested in vivo for their antidyslipidemic activity in high fat diet (HFD) induced dyslipidemic hamsters. Activity guided isolation resulted in identification of antidyslipidemic compounds beta-AA and beta-AP. Compounds beta-AA and beta-AP decrease the levels of LDL by 36% and 44%, and increase the HDL-C/TC ratio by 49% and 28%, respectively, at a dose of 10mg/kg. In addition, the isolated compounds beta-AA and beta-AP showed significant HMG-CoA-reductase inhibition, which was further established by docking studies.

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