VindolinineCAS# 5980-02-9 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 5980-02-9 | SDF | Download SDF |
| PubChem ID | 24148538 | Appearance | Powder |
| Formula | C21H24N2O2 | M.Wt | 336.43 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C23CC(C14C5(C2N(CC5)CC=C3)C6=CC=CC=C6N4)C(=O)OC | ||
| Standard InChIKey | JSLDLCGKZDUQSH-SBDPWIONSA-N | ||
| Standard InChI | InChI=1S/C21H24N2O2/c1-13-19-8-5-10-23-11-9-20(18(19)23)14-6-3-4-7-16(14)22-21(13,20)15(12-19)17(24)25-2/h3-8,13,15,18,22H,9-12H2,1-2H3/t13-,15+,18+,19+,20-,21-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Vindolinine is a natural product from Catharanthus roseus (L.) G. Don. |
| In vitro | Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).[Pubmed: 25665941 ]Fitoterapia. 2015 Apr;102:182-8.
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Vindolinine Dilution Calculator
Vindolinine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9724 mL | 14.8619 mL | 29.7239 mL | 59.4477 mL | 74.3097 mL |
| 5 mM | 0.5945 mL | 2.9724 mL | 5.9448 mL | 11.8895 mL | 14.8619 mL |
| 10 mM | 0.2972 mL | 1.4862 mL | 2.9724 mL | 5.9448 mL | 7.431 mL |
| 50 mM | 0.0594 mL | 0.2972 mL | 0.5945 mL | 1.189 mL | 1.4862 mL |
| 100 mM | 0.0297 mL | 0.1486 mL | 0.2972 mL | 0.5945 mL | 0.7431 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).[Pubmed:25665941]
Fitoterapia. 2015 Apr;102:182-8.
Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, Vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and IR. Vindogentianine is a dimer containing a vindoline moiety coupled to a gentianine moiety. After 24h incubation, vindogentianine exhibited no cytotoxic effect in C2C12 mouse myoblast and beta-TC6 mouse pancreatic cells (IC50>50mug/mL). Real-time cell proliferation monitoring also indicated vindogentianine had little or no effect on C2C12 mouse myoblast cell growth at the highest dose tested (200mug/mL), without inducing cell death. Vindogentianine exhibited potential hypoglycemic activity in beta-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition. However, in vitro alpha-amylase and alpha-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine. This suggests that hypoglycemic activity of vindogentianine may be due to the enhancement of glucose uptake and PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.
