Vindolinine

CAS# 5980-02-9

Vindolinine

Catalog No. BCN7822----Order now to get a substantial discount!

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Quality Control of Vindolinine

Number of papers citing our products

Chemical structure

Vindolinine

3D structure

Chemical Properties of Vindolinine

Cas No. 5980-02-9 SDF Download SDF
PubChem ID 24148538 Appearance Powder
Formula C21H24N2O2 M.Wt 336.43
Type of Compound Miscellaneous Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1C23CC(C14C5(C2N(CC5)CC=C3)C6=CC=CC=C6N4)C(=O)OC
Standard InChIKey JSLDLCGKZDUQSH-SBDPWIONSA-N
Standard InChI InChI=1S/C21H24N2O2/c1-13-19-8-5-10-23-11-9-20(18(19)23)14-6-3-4-7-16(14)22-21(13,20)15(12-19)17(24)25-2/h3-8,13,15,18,22H,9-12H2,1-2H3/t13-,15+,18+,19+,20-,21-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Vindolinine

The leaves of Catharanthus roseus (L.) G. Don.

Biological Activity of Vindolinine

DescriptionVindolinine is a natural product from Catharanthus roseus (L.) G. Don.
In vitro

Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).[Pubmed: 25665941 ]

Fitoterapia. 2015 Apr;102:182-8.


METHODS AND RESULTS:
Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, Vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and IR. Vindogentianine is a dimer containing a vindoline moiety coupled to a gentianine moiety. After 24h incubation, vindogentianine exhibited no cytotoxic effect in C2C12 mouse myoblast and β-TC6 mouse pancreatic cells (IC50>50μg/mL). Real-time cell proliferation monitoring also indicated vindogentianine had little or no effect on C2C12 mouse myoblast cell growth at the highest dose tested (200μg/mL), without inducing cell death. Vindogentianine exhibited potential hypoglycemic activity in β-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition. However, in vitro α-amylase and α-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine.
CONCLUSIONS:
This suggests that hypoglycemic activity of vindogentianine may be due to the enhancement of glucose uptake and PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.

Vindolinine Dilution Calculator

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Vindolinine Molarity Calculator

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Preparing Stock Solutions of Vindolinine

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9724 mL 14.8619 mL 29.7239 mL 59.4477 mL 74.3097 mL
5 mM 0.5945 mL 2.9724 mL 5.9448 mL 11.8895 mL 14.8619 mL
10 mM 0.2972 mL 1.4862 mL 2.9724 mL 5.9448 mL 7.431 mL
50 mM 0.0594 mL 0.2972 mL 0.5945 mL 1.189 mL 1.4862 mL
100 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.5945 mL 0.7431 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Vindolinine

Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae).[Pubmed:25665941]

Fitoterapia. 2015 Apr;102:182-8.

Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, Vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and IR. Vindogentianine is a dimer containing a vindoline moiety coupled to a gentianine moiety. After 24h incubation, vindogentianine exhibited no cytotoxic effect in C2C12 mouse myoblast and beta-TC6 mouse pancreatic cells (IC50>50mug/mL). Real-time cell proliferation monitoring also indicated vindogentianine had little or no effect on C2C12 mouse myoblast cell growth at the highest dose tested (200mug/mL), without inducing cell death. Vindogentianine exhibited potential hypoglycemic activity in beta-TC6 and C2C12 cells by inducing higher glucose uptake and significant in vitro PTP-1B inhibition. However, in vitro alpha-amylase and alpha-glucosidase inhibition assay showed low inhibition under treatment of vindogentianine. This suggests that hypoglycemic activity of vindogentianine may be due to the enhancement of glucose uptake and PTP-1B inhibition, implying its therapeutic potential against type 2 diabetes.

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