Oxybuprocaine HCl

Oxybuprocaine HCl is a local anesthetic, which is used especially in ophthalmology and otolaryngology.

Comparison of the influence of nonpreserved oxybuprocaine and a preserved artificial tear (thera tears) on human corneal thickness measured by two pachymeters.[Pubmed:23331053]

J Ocul Pharmacol Ther. 2013 Jun;29(5):462-8.

PURPOSE: To compare the effect of nonpreserved oxybuprocaine and preserved artificial tears on central corneal thickness (CCT) obtained by 2 pachymeters. METHODS: In this prospective, placebo-controlled study, involving a random sample of 100 eyes of 50 subjects, aged 24+/-2.3 years, CCT readings were obtained in 2 separate sessions with the Topcon SP-3000P and ultrasound pachymetry (USP), respectively, before, 5 and 10 min after instillation of a drop each of either oxybuprocaine hydrochloride (Oxybuprocaine HCl) (group 1) or carboxymethylcellulose sodium, thera tears (group 2), and placebo. RESULTS: The baseline mean CCT for SP-3000P was 509+/-38 mum and 542+/-36 mum for USP. No statistical significant differences between baseline CCTs (P>0.05 for both devices) in both groups. In both group experimental eyes, neither SP-3000P nor USP-measured CCTs varied significantly from the control eyes at 5 (P>0.05) and 10 (P>0.05) mins postinstillation of drops in both sessions. In group one, the 95% confidence intervals (CIs) for the SP-3000P CCTs were similar at 5 (-16 to 17 mum) and 10 min (-16 to 17 mum), but in the USP-measured CCTs, it was wider at 10 min (-41 to 46 mum) than at 5 min (-30 to 41 mum) postinstillation. In group two, the 95% CIs at 5 and 10 mins postinstillation, respectively, ranged between -20 and 47 mum, -21 and 43 mum (SP-3000P) and -29 and 23 mum, -26 and 23 mum (USP). Within groups and between groups, variations in CCT were similar at both times intervals in all comparisons. CONCLUSION: Although Oxybuprocaine HCl and thera tears consistently did not affect the mean CCT obtained by both devices at both time intervals, variation in SP-3000P measured CCT was more consistent in both sessions and narrower in relation to USP-measured CCT. It may be reasonable to suggest that measurements of CCT in normal patients be taken before examinations requiring instillation of anesthetics or such measurements when obtained postinstillation of either oxybuprocaine or preserved artificial tears be interpreted with caution.

[Excimer laser correction of myopia].[Pubmed:8225068]

Harefuah. 1993 Jul;125(1-2):4-6, 64.

Excimer laser photorefractive keratectomy was performed on 100 myopic eyes. The preoperative spherical equivalent of myopia ranged from -2.00 to -9.99 diopters (D), mean -4.80 +/- 2.20 D. The procedure was performed under local anesthesia using 0.4% topical benoxinate HCl; corticosteroid eye drops were then used for up to 3 months. All patients achieved corrected visual acuity within 1 line of corrected preoperative visual acuity. The only complication was subepithelial reticular haze seen in all patients, which peaked at 4 weeks after the procedure and gradually diminished within 3 months. After follow-up of from 6-11 months, 93% of patients had achieved uncorrected visual acuity of 6/12 or better. Mean postoperative refraction was -0.20 +/- 0.97 D. 69% achieved a correction within +/- 0.50 diopter of emmetropia, 85% within +/- 1.00 D and 96% achieved corrected visual acuity of within 1 line of preoperative corrected visual acuity. This study and those in the literature show excimer laser to be a promising surgical treatment for myopia.

Changes in central corneal thickness values after instillation of oxybuprocaine hydrochloride 0.4%.[Pubmed:22704944]

Cont Lens Anterior Eye. 2012 Oct;35(5):199-202.

PURPOSE: To assess the variation in central corneal thickness (CCT) following the instillation of oxybuprocaine hydrochloride (0.4%), in normal subjects. METHODS: This was a randomized, prospective study of CCT measurements (before and after the instillation of topical anaesthesia) obtained with the Topcon SP-3000P noncontact specular microscope, in 60 eyes of thirty subjects. The subjects' mean age was 20+/-1 years (mean+/-SD). In each subject, one eye was treated with one drop of oxybuprocaine hydrochloride (HCl) and the fellow eye with one drop of normal saline (control). The SP-3000P CCT readings were first obtained before instillation (baseline) and monitored every 30 s after instillation of each eye drop for a period of 10 min. RESULTS: The mean baseline CCT for oxybuprocaine was 526+/-23 mum. Ten minutes after, it was 526+/-24 mum. In the control, the mean CCT was 526+/-27 mum, 10 min after it was 526+/-28 mum. The mean variation in CCT measurement was -0.7+/-3.1 (5.5 to -6.8 mum, 95% CI) for oxybuprocaine and -0.6+/-4.1 mum (7.5 and -8.6 mum, 95% CI) for the fellow eyes (P>0.05). There was no significant variation among the 20 CCT columns for either oxybuprocaine or the control group (P>0.05 for both). CONCLUSIONS: One drop of topical oxybuprocaine 0.4% did not cause a significant change in CCT at up to 10 min following instillation. However, higher differences were observed at 2.30 min and 4.30 min after instillation.

[The potential uses and limitations of the flexible laryngoscopy under local anesthesia in clinical practice].[Pubmed:10506496]

HNO. 1999 Aug;47(8):702-5.

Microsurgery of the larynx is commonly performed as direct laryngoscopy (DL) under general anesthesia. An alternative in selected cases is flexible laryngoscopy (FSL) under local anesthesia. We used a flexible laryngoscope that contained an additional working tunnel (Olympus ENF Type T3). Local anaesthesia of the larynx was achieved with 1% oxybuprocaine-HCl. Tissue samples were taken under endoscopic view and control. Twenty-five patients were studied and had benign lesions of the larynx or were being followed after treatment for cancer. The examination was tolerated well by all patients. The handling of the endoscope allowed precise targeting and sample taking. Due to the 2.2 mm diameter of the forceps the sizes of the biopsies were also limited. However, nearly all of the biopsies taken allowed sufficient histological examination. The advantage of the FSL was its simplicity and the minor inconvenience for patients. Although true histological results of suspect findings are possible, limitations in examining the hypopharynx prevent true staging of cancer patients. In general, FCL is a worth-while complement to DL.

First derivative spectrophotometric and LC determination of benoxinate hydrochloride and its degradation products.[Pubmed:10719904]

J Pharm Biomed Anal. 2000 Mar;22(2):215-34.

Two methods are presented for the determination of benoxinate HCI and its acid and alkali-induced degradation products using first derivative (1D) spectrophotometry with zero-crossing measurements and liquid chromatography. Benoxinate HCl was determined by measurement of its first derivative amplitude in mcllvaine's-citric acid phosphate buffer pH 7.0 at 268.4 and 272.4 nm in the presence of its alkali- and acid-induced degradation products, respectively. The acid- and alkali-induced, degradation products were determined by measurement of their first derivative amplitude in the same solvent at 307.5 nm. The LC method depends upon using a mu bondapak CN column with a mobile phase consisting of acetonitrile-water triethylamine (60:40:0.01, v/v) and adjusted to apparent pH 7. Quantitation was achieved with UV detection at 310 nm based on peak area. The proposed methods were utilized to investigate the kinetics of the acidic and alkaline degradation processes at different temperatures. The pH-rate profile of degradation of benoxinate HCl in Britton-Robinson buffer solutions was studied.

Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology.

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