Products with Anti-cerebral ischemia bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1684 | Rutin |
| Rutin has antioxidant, anti-inflammatory, anti-allergic, gastroprotective, anticonvulsant, anti-angiogenic and antiviral properties, it may protect against spatial memory impairment induced by trimethyltin. Rutin exerts anti-inflammatory effects in UVB-irradiated mouse skin by inhibiting expression of COX-2 and iNOS, which is attributable to its suppression of p38 MAP kinase and JNK signaling responsible for AP-1 activation. | |
| BCN2230 | S-Adenosyl-L-methionine tosylate |
| 1. S-adenosyl-L-methionine tosylate has a beneficial effect on the outcome of ischemic injury by reducing the blood-brain barrier (BBB) breakdown and neuronal death. | |
| BCN2381 | 3-n-Butylphthalide |
| Dl-3-n-Butylphthalide has antihypertensive effects, may slow the progression of hypertensive nephropathy by a variety of mechanisms.3-n-Butylphthalide is effective for improving cognitive and global functioning in patients with subcortical VCIND and exhibits good safety, this effect might be mediated by preventing the decline of the central cholinergic system. | |
| BCN2383 | Gardenoside |
| Gardenoside has hepatoprotective, pain‑relieving, and anti-mastitis effects. it may be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB activity. Gardenoside may be considered potential drug candidates that target P2X3 and P2X7 purine receptors. | |
| BCN2399 | Nigranoic acid |
| 1. Nigranoic acid shows activity in several anti-HIV reverse transcriptase and polymerase assays. 2. Nigranoic acid is able to promote NO production and stimulate phosphorylation of ERK1/2 through Ca(2+) influx, further impact expression of BDNF and c-fos, may be benefit to enhance mental and intellectual functions. 3. Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. 4. Nigranoic acid exhibits significant inhibitory activity against HNE with the IC50 value of 3.77 μM, and six esters displayed considerable inhibitory effects on HNE with IC50 values in the range of 2.61-8.95 μM. | |
