Products with Anti-inflammatory bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5746 | beta-Amyrin |
| 1. alpha- and beta-Amyrin have hepatoprotective potential against toxic liver injury, the diminution in oxidative stress and toxic metabolite formation as likely mechanisms involved in its hepatoprotection. 2. alpha- and beta-Amyrin have antinociceptive properties in inflammatory models of pain, the mechanisms involved in their action are not completely understood but seem to involve the inhibition of protein kinase A- and protein kinase C-sensitive pathways. 3. alpha- and beta-Amyrin have anti-inflammatory potential, they retard acute inflammation in rat model of periodontitis and warrant further study on its efficacy to prevent chronic periodontitis-associated bone loss. 4. alpha- and beta-Amyrin mixture has gastro-protective activity, the mechanism involves at least in part the activation of capsaicin-sensitive primary afferent neurons. 5. alpha- and beta-Amyrin mixture has sedative and anxiolytic effects, the mechanism may involve an action on benzodiazepine-type receptors, and also an antidepressant effect where noradrenergic mechanisms will probably play a role. 6. Beta-Amyrin can enhance the total sleeping behavior in pentobarbital-induced sleeping model via the activation of GABAergic neurotransmitter system through GABA content in the brain. 7. beta-Amyrin has antiviral activity. | |
| BCN5747 | Friedelin |
| Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.Friedelin rich fraction (IND-HE) shows estrogenic activity as indicated by vaginal cornification, increase in uterine weight and rise in serum estrogen. Friedelin may be beneficial to mimic insulin action that would be useful in the treatment of diabetes type 2 patients. | |
| BCN5753 | Hedychenone |
| Hedychenone has anti-inflammatory activity, it also shows potent in vitro cytotoxic activity against cancerous cells. | |
| BCN5754 | Tirotundin |
| 1. Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. 2. Tirotundin shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory mediators such as cytokines and chemokines is reduced. | |
| BCN5758 | 4,9-Dihydroxy-alpha-lapachone |
| 1. 4,9-Dihydroxy-alpha-lapachone has antitumor-promoting effects, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. 2. 4,9-Dihydroxy-alpha-lapachone exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC(50) value of 2.73 microM. | |
