Products with Anti-inflammatory bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5638 | Neoechinulin A |
| 1. Neoechinulin A may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits. 2. Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways. 3. Neoechinulin A may ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities. 4. Neoechinulin A has a potential to be developed as a modulator of neuroinflammatory process in Alzheimer's disease. | |
| BCN5650 | Matrine |
| Matrine, a novel autophagy inhibitor, possesses anti-inflammation, immunosuppression, anti-fibrotic and anticancer activities, it could inhibit cell proliferation and induce apoptosis of SGC-7901 cells in vitro by up-regulating Fas/FasL expression and activating caspase-3 enzyme. Matrine can be a potential candidate to fight against Candida-related infections by regulating yeast-to-hypha transition. | |
| BCN5653 | Kaempferol |
| 1. Kaempferol activates LXR-β and suppresses SREBP-1 to enhance symptoms in metabolic syndrome. 2. Kaempferol exerts a potent inhibitory effect on in vitro bone resorption. 3. Kaempferol has anti-inflammatory action, can prevent and treat inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis. 4. Kaempferol has therapeutic potential for the prevention and treatment of thrombovascular diseases, can enhance relaxations caused by endothelium-derived and exogenous NO as well as those due to endothelium-dependent hyperpolarization. 5. Kaempferol can inhibit cancer cell invasion through blocking the PKCδ/MAPK/AP-1 cascade and subsequent MMP-9 expression and its activity, may act as a therapeutic potential candidate for cancer metastasis. 6. Kaempferol is an autophagic enhancer, has a more general protection in Parkinson's disease, can mediate antiapoptotic and antioxidant effects is the enhancement of mitochondrial turnover by autophagy. | |
| BCN5654 | Hesperidin |
| Hesperidin has antioxidative, anti-inflammatory, vasoprotective,and anticarcinogenic effects, it induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Hesperidin also exerts its protective effect against CYP-induced hepatotoxicity through upregulation of hepatic PPARγ expression and abrogation of inflammation and oxidative stress. | |
| BCN5656 | Tricin |
| 1. Tricin is evaluated as a type of tyrosinase inhibitor. 2. Tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia. 3. Tricin exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade. 4. Tricin may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis. 5. Tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. | |
