Products with Anti-inflammatory bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5109 | 3-Geranyl-4-methoxybenzoic acid |
| 1. 3-Geranyl-4-methoxybenzoic acid exhibits stronger inhibition effect on the activation of hyaluronidase than that of tranilast. | |
| BCN5114 | (-)-Epiafzelechin |
| 1. (-)-Epiafzelechin exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. 2. (-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment. 3. (-)-Epicatechin shows zero and/or the lowest activities against pancreatic lipase (IC50 > 20 microM). 4. Epiafzelechin has antioxidant properties. | |
| BCN5117 | Crebanine |
| Crebanine has antiarrhythmic, anticancer, anti-inflammatory, and analgesic properties; it can significantly improve the cognitive deficits induced by scopolamine, via the alpha-7 nicotinic acetylcholine receptor, crebanine or its scaffold can be used as the starting point to develop a drug for Alzheimer's disease.Crebanine can reduce TNF-α-induced cancer cell proliferation, invasion, and survival by suppressing NF-κB activity and expression profile of its downstream genes. | |
| BCN5122 | Isoferulic acid |
| Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabetic complications via inhibition of advanced glycation end products (AGEs) formation and oxidation-dependent protein damage. Isoferulic acid is a novel and potent inhibitor of murine IL-8 production, it also has inhibitory effect on mushroom tyrosinase.3-Hydroxy-4-methoxycinnamic acid shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties, it is an anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation. | |
| BCN5130 | Velutin |
| Velutin has strong anti-inflammatory activity, it can effectively inhibit the expression of proinflammatory cytokines TNF-α and IL-6 in low micromole levels by inhibiting NF-κB activation and p38 and JNK phosphorylation. Velutin controls HIF-1α activity during PgLPS-activated osteoclastogenesis probably through modulation of the NF-κB pathway, perhaps it could be used therapeutically to prevent bone loss seen in periodontitis.Velutin can induce apoptosis in tumor cells. | |
