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BCN6333 |
Licochalcone B
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Licochalcone B has antitumor, antimetastatic, cardioprotective, antioxidant, antiapoptotic, and anti-inflammatory effects, it can significantly inhibit LPS-induced phosphorylation at serine 276 and transcriptional activation of NF-KB. Licochalcone B can protect the liver from carbon tetrachloride (CCl4)-induced injury, the protection may be due to inhibition of p38 and NFκB signaling, which subsequently reduces inflammation in the liver. |
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BCN6334 |
Licochalcone C
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1. Licochalcone C shows potent antioxidant properties and inhibition of bacterial growth and cellular respiration.
2. Licochalcone C has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activities.
3. Licochalcone C and licochalcone A exhibit inhibitory activity with cytotoxicity in a rat basophilic leukemia cell line, RBL-2H3.
4. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells, it may be a potential adjuvant therapeutic agent for bladder cancer. |
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BCN6338 |
Neferine
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Neferine, a autophagy inducer, which has anti-amnesic, sedative, anti-anxiety, antidepressant, cardioprotective, anti- pulmonary fibrosis,anti-cancer, antioxidant and anti-inflammatory capacities. It inhibited ChEs, BACE1, NF-kappaB, PI3K/Akt/mTOR pathway, Neferine has effects similar to rosiglitazone in decreasing fasting blood glucose, insulin, TG, TNF-alpha and enhancing insulin sensitivity in insulin resistant rats. |
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BCN6339 |
Linalool
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Linalool, is a competitive antagonist of NMDA receptors, which has anti-inflammatory, antinociceptive, anti-anxiety, local anaesthetic, anti-leishmanicidal, and insecticidal properties. Linalool has dose-dependent marked sedative effects at the central nervous system (CNS), including hypnotic, anticonvulsant and hypothermic properties, it also has an inhibitory effect on the acetylcholine (ACh) release and on the channel open time in the mouse neuromuscular junction. The purified linalool fraction is only inhibitory for C. albicans. |
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BCN6342 |
Methyl protodioscin
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Methyl protodioscin has anti-thrombosis, antiosteoporotic, anti-myocardial infarction, and cytotoxic activities. Methyl protodioscin shows strong cytotoxicity against most cell lines from solid tumors with GI50 ≤10.0 microM, but moderate cytotoxicity is shown against leukemia cell lines with GI50 10-30 microM. It potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides, it also can treat diverse inflammatory pulmonary diseases. |
