Products with Anti-mitotic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4732 | Narciclasine |
| 1. Narciclasine displays marked proapoptotic and cytotoxic activity, as does pancratistatin, and significant in vivo anticancer effects in various experimental models, but it is also associated with severe toxic side effects. 2. Narciclasine acts on the auxin signaling pathway upstream of TIR1, which modulates Aux/IAA protein degradation, and thereby affects the auxin-mediated responses in Arabidopsis roots, inhibits the root hair development of lettuce seedlings. 3. The alkaloid Narciclasine is the bioactive compound responsible for the anti-inflammatory action of HCE. | |
| BCN5008 | Cornin |
| Verbenalin has been reported to exhibit uterine stimulant activity and demonstrated cardioprotection against experimental myocardial ischemic injury and cerebral ischemia injury. Cornin induces angiogenesis in vitro via a programmed PI3K/Akt/eNOS/VEGF signaling axis, it also has antimitotic action on dividing cell. | |
| BCN5829 | Kadsuracoccinic acid A |
| 1. Kadsuracoccinic acid A has anticancer activity. 2. Kadsuracoccinic acid A induces significant cleavage arrest. 3. Kadsuracoccinic acid A may be related to the preservation of the progression of the M phase. | |
| BCN6271 | Colchicine |
| Colchicine is a tubulin inhibitor, and a microtubule polymerization inhibitor with an IC50 of 3 nM. It prevents amyloidosis in our high-risk population and that it can prevent additional deterioration of renal function in patients with amyloidosis who have proteinuria but not the nephrotic syndrome. Colchicine has anti-mitotic activity, it can be used to treat familial mediterranean fever, and as a lead compound for the generation of potent anti-cancer drugs. | |
| BCN6342 | Methyl protodioscin |
| Methyl protodioscin has anti-thrombosis, antiosteoporotic, anti-myocardial infarction, and cytotoxic activities. Methyl protodioscin shows strong cytotoxicity against most cell lines from solid tumors with GI50 ≤10.0 microM, but moderate cytotoxicity is shown against leukemia cell lines with GI50 10-30 microM. It potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides, it also can treat diverse inflammatory pulmonary diseases. | |
