Products with Antileukaemic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5236 | Pinusolide |
| 1. Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension . 2. Pinusolide has antileukemic potential, it not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 microM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB. 3. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes. 4. Pinusolide can protect neuronal cells from staurosporine (STS) -induced apoptosis, probably by preventing the increase in [Ca2+]i and cellular oxidation caused by STS, and indicate that it could be used to treat neurodegenerative diseases. 5. Pinusolide shows potent inhibition of 5-LO dependent LTC4 generation, which requires both suppression of calcium influx and JNK phosphorylation. | |
| BCN5257 | Quercetin 3,4'-dimethyl ether |
| 1. Quercetin 3,4’-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM). 2. 5,7,3'-Trihydroxy-3,4'-dimethoxyflavone (Quercetin 3,4’-dimethyl ether ) has high cytotoxic against leukemia cells, it induces cell death is mediated by an intrinsic dependent apoptotic event involving mitochondria and MAPKs, and through a mechanism independent of the generation of reactive oxygen species, suggests that it could be useful in the development of novel anticancer agents. 3. Quercetin 3,4’-dimethyl ether shows anti-inflammatory activity. | |
| BCN5302 | Cabraleone |
| 1. The mixture of cabraleone and ocotillone shows cytotoxicity against HL-60 leukaemia cell line. | |
| BCN5352 | Icaritin |
| Icaritin, a potent inhibitor of transcription factor SREBPs, which exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, hormone regulation, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings. | |
| BCN5354 | Acetate gossypol |
| Acetate gossypol has antifertility action. Acetate gossypol is a potent inhibitor of Bcl-2 and Bcl-xl, it has significant antiproliferative and antiapoptotic effects on multiple myeloma cells in vitro and in vivo, it also has apoptosis-inducing activity in primary cultured leukemia cells. | |
