Products with Antileukaemic bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5543 | Berbamine |
| Berbamine is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia.Berbamine confers cardioprotection against I/R injury by attenuating [Ca(2+)inf(i) overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoK(ATP) channel. | |
| BCN5667 | Lochnerine |
| 1. Lochnerine shows potent vasorelaxant activity. 2. Lochnerine shows some antitumor activity, it can bring about complete inhibition of cell growth in P388 leukemia cells in vitro. | |
| BCN5676 | Quercetin 3-O-robinobioside |
| 1.Quercetin-3-O-robinobioside is a quercetin-derived flavonol, exhibits antioxidant activities. 2.Quercetin-3-O-robinobioside exhibits in-vitro inhibitory activities against leukemia K562 cells. | |
| BCN5687 | Magnolol |
| Magnolol is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively. Magnolol has antifungal, antibacterial, anti-oxidative, antidepressant-like, anti- tumor, and neuroprotective effects, it also prevents skin photoaging in UVB-irradiated hairless mice. Magnolol has a wide spectrum of targets including TNF-α, NF-KB, GSK3β. | |
| BCN5808 | Wulignan A1 |
| Wulignan A1 exhibits activity against leukemia P-388 in vitro; it also may have anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities. | |
