Products with Antioxidants bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6356 | Sinensetin |
| Sinensetin is a polymethoxylated flavonoids in citrus fruit, as a novel antiangiogenesis agent, has potential for anti-carcinogenesis, antitumor, and cardiovascular protective activities. Sinensetin has antioxidative effect and has anti-inflammatory by regulating the protein level of inhibitorκB-α, it enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes. | |
| BCN6475 | Okanin |
| 1. Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. 2. Okanin shows significant protective effects against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC50 value of 29.8±1.1 uM. 3. Okanin can inhibit nitric oxide production and inducible nitric oxide synthase expression via nuclear factor-erythroid 2-related factor 2-dependent heme oxygenase-1 expression in lipopolysaccharide-activated macrophages. 4. Okanin attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways, suggests that okanin may have potential as a nutritional preventive strategy for neurodegenerative disorders. | |
| BCN6476 | Isookanin |
| 1. Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with the IC50 value of 7.9 ± 0.53 uM. 2. Isookanin is a potent inhibitor of α-amylase (IC₅₀=0.447 mg/ml). | |
| BCN6477 | Marein |
| 1. Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, indicates that marein may be a potent compound for preventing/counteracting diabetic encephalopathy. 2. Marein shows antioxidant activity. 3. Marein can improve insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. 4. Marein shows Histone deacetylase enzymes (HDACs) inhibitory activity and it also can inhibit TNFα-induced NF-κB activation. | |
| BCN6479 | Desoxyrhapontigenin |
| 1. Desoxyrhapontigenin shows significant monoamine oxidase inhibitory activities with the IC50 value of 11.5 ± 1.1 uM. 2. Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1(HO-1) expression in macrophages and inflammatory lung injury, and HO-1 is an important anti-inflammatory, antioxidative and cytoprotective enzyme. 3. Desoxyrhapontigenin shows anti-inflammatory properties by the inhibition of iNOS and COX-2 expression via the down-regulation of the MAPK signaling pathways and the inhibition of NF-κB and Akt activation. 4. Desoxyrhapontigenin and desoxyrhaponticin have significant hypoglycemic and antioxidant effects. | |
