Products with Antiviral bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5735 | Andrographolide |
| Andrographolide is an antiinflammatory, antiviral, anti-cancer , hepatoprotective, antithrombotic, hypotensive and antiatherosclerotic drug, it can cure hyperpigmentation disorders. Andrographolide protects against chemical-induced oxidative damage by up-regulating the gene transcription and activity of antioxidant enzymes in various tissues.Andrographolide has potential as a leading compound in the prevention or treatment of obesity and insulin resistance, can ameliorate lipid metabolism and improve glucose use in mice with HFD-induced obesity. | |
| BCN5743 | Myriceric acid B |
| 1. Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. 2. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 value of 6.8 uM, it also exhibits cytotoxic activity towards the MOLT-3 cell line with IC50 values of 3.9 uM. | |
| BCN5746 | beta-Amyrin |
| 1. alpha- and beta-Amyrin have hepatoprotective potential against toxic liver injury, the diminution in oxidative stress and toxic metabolite formation as likely mechanisms involved in its hepatoprotection. 2. alpha- and beta-Amyrin have antinociceptive properties in inflammatory models of pain, the mechanisms involved in their action are not completely understood but seem to involve the inhibition of protein kinase A- and protein kinase C-sensitive pathways. 3. alpha- and beta-Amyrin have anti-inflammatory potential, they retard acute inflammation in rat model of periodontitis and warrant further study on its efficacy to prevent chronic periodontitis-associated bone loss. 4. alpha- and beta-Amyrin mixture has gastro-protective activity, the mechanism involves at least in part the activation of capsaicin-sensitive primary afferent neurons. 5. alpha- and beta-Amyrin mixture has sedative and anxiolytic effects, the mechanism may involve an action on benzodiazepine-type receptors, and also an antidepressant effect where noradrenergic mechanisms will probably play a role. 6. Beta-Amyrin can enhance the total sleeping behavior in pentobarbital-induced sleeping model via the activation of GABAergic neurotransmitter system through GABA content in the brain. 7. beta-Amyrin has antiviral activity. | |
| BCN5757 | Eichlerianic acid |
| 1. Eichlerianic acid shows weak cytotoxicity (IC50 6.87 to >40 μM) against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480). 2. Eichlerianic acid is a trypanocidal compound with an IC50 value of 10 mg/mL. 3. Eichlerianic acid may have antiviral activity against Herpes simplex virus types I and II in vitro. | |
| BCN5767 | Penduletin |
| 1. Penduletin shows anti- tumor cells activity. 2. Penduletin significantly reduces TGF-β1 production. 3. Penduletin has strong activity in vitro against EV71 with low cytotoxicity. 4. Penduletin inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. 5. Penduletin may have anti-inflammatory activity, it can partially inhibit synovial phospholipase A2 activity. | |
