Products with Antiviral bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2409 | Lycorine |
| Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.Lycorine has antiviral, and anti-cancer effects, the mechanisms of Lycorine on the multiple myeloma cell line ARH-77 are associated with G1 phase cell cycle arrest, mitochondrial dysfunction, reactive oxygen species (ROS) generation, ATP depletion, and DNA damage. | |
| BCN2439 | Ganoderic acid Y |
| 1. Ganoderic acid Y significantly inhibits the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating. | |
| BCN2440 | Ganoderic acid Z |
| 1. Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines. 2. The binding affinities of ganoderic acid DM and Z (ΔGbind, −16.83 and−10.99 kcal mol−1) are comparable to that of current commercial drug oseltamivir (−23.62 kcal mol−1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors. | |
| BCN2444 | Ganolucidic acid A |
| 1. Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. 2. Ganolucidic acid A shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM. | |
| BCN2448 | Ganoderone A |
| 1. Ganoderone A exhibits potent inhibitory activity against herpes simplex virus. 2. Ganoderone A exhibits strong inhibitory activities against Vero cells (IC50 is 0.3 ug/mL). 3. Ganoderone A has inhibition against cancer cell lines K562, SW620, and HL60, the 50% inhibiting concentration( IC50) are 9. 61, 22. 38, 7. 14 mg/L, respectively. | |
