Products with Cytoprotective bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1819 | Trimethylamine oxide |
| 1. Trimethylamine oxide has a thermo-protective role in these cells, thus eliminating the need for a heat shock response. 2. Trimethylamine oxide can stimulate both the anaerobic growth rate and the growth yield of Proteus NTHC 153 by serving as a terminal electron acceptor in an oxidative phosphorylation process. | |
| BCN2309 | (+)-Catechin hydrate |
| (+)-Catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. | |
| BCN2356 | Diosmetin |
| Diosmetin has anti-osteoporosis, cytoprotective, antibacterial, anti-pigmentation, anti-inflammatory and antioxidant properties, it induces osteoblastic differentiation through the PKCδ-Rac1-MEK3/6-p38 and PKCδ-Rac1-MEK1/2- ERK1/2-Runx2 pathways.Diosmetin has intracellular antioxidant detoxifying effect, the mechanism is associated with both nonenzymatic and enzymatic defense systems.Diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation. | |
| BCN2756 | Hirsuteine |
| Hirsuteine exhibits potent neuroprotective effects against glutamate-induced HT22 cell death. Hirsuteine non-competitively antagonizes nicotine-evoked dopamine release by blocking ion permeation through nicotinic receptor channel complexes. | |
| BCN2769 | Asarinin |
| Asarinin, a mammalian lignan precursor, has immunosuppression activity and can inhibit acute rejection in vitro. Asarinin may have a role on TLR4 pathway and produce prolongation of allograft heart survival. Asarinin induces dopamine biosynthesis via activation of the PKA-CREB-TH system and protects against 6-OHDA-induced cytotoxicity by inhibiting the sustained activation of the ERK-p38MAPK-JNK1/2-caspase-3 system in PC12 cells. | |
