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(+)-Catechin hydrate

CAS# 225937-10-0

(+)-Catechin hydrate

Catalog No. BCN2309----Order now to get a substantial discount!

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(+)-Catechin hydrate: 5mg $23 In Stock
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Quality Control of (+)-Catechin hydrate

Number of papers citing our products

Chemical structure

(+)-Catechin hydrate

3D structure

Chemical Properties of (+)-Catechin hydrate

Cas No. 225937-10-0 SDF Download SDF
PubChem ID 107957 Appearance Powder
Formula C15H16O7 M.Wt 308.28
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility DMSO : 150 mg/mL (Need ultrasonic and warming)
Chemical Name (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol;hydrate
SMILES C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O.O
Standard InChIKey OFUMQWOJBVNKLR-NQQJLSKUSA-N
Standard InChI InChI=1S/C15H14O6.H2O/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7;/h1-5,13,15-20H,6H2;1H2/t13-,15+;/m0./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of (+)-Catechin hydrate

The herbs of Camellia sinensis

Biological Activity of (+)-Catechin hydrate

Description(+)-Catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
TargetsCOX-1
In vivo

Effect of (+)-catechin hydrate on oxidative stress induced by high sucrose and high fat diet in male Wistar rats.[Pubmed: 24266106]

Indian J Exp Biol. 2013 Oct;51(10):823-7.


METHODS AND RESULTS:
Increased lipid peroxidation and reduced glutathione levels in liver of rats fed high sucrose high fat (HSHF) diet were normalized by concomitant administration of (+)-Catechin hydrate. Plasma non-enzymatic antioxidants viz. alpha-tocopherol, ascorbic acid and total thiols decrease were also significantly less in rats administered with (+)-Catechin hydrate concomitantly with HSHF diet. Thus the present results indicate that (+)-Catechin hydrate has antioxidant activity and is effective in reducing oxidative stress.
CONCLUSIONS:
The study is of clinical importance as oxidative stress is known to be the cause of many clinical manifestations viz. cancer, Parkinson's disease, atherosclerosis, heart failure, myocardial infarction and many other diseases.

(+)-Catechin hydrate Dilution Calculator

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(+)-Catechin hydrate Molarity Calculator

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Preparing Stock Solutions of (+)-Catechin hydrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2438 mL 16.219 mL 32.438 mL 64.8761 mL 81.0951 mL
5 mM 0.6488 mL 3.2438 mL 6.4876 mL 12.9752 mL 16.219 mL
10 mM 0.3244 mL 1.6219 mL 3.2438 mL 6.4876 mL 8.1095 mL
50 mM 0.0649 mL 0.3244 mL 0.6488 mL 1.2975 mL 1.6219 mL
100 mM 0.0324 mL 0.1622 mL 0.3244 mL 0.6488 mL 0.811 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on (+)-Catechin hydrate

Effect of (+)-catechin hydrate on oxidative stress induced by high sucrose and high fat diet in male Wistar rats.[Pubmed:24266106]

Indian J Exp Biol. 2013 Oct;51(10):823-7.

Increased lipid peroxidation and reduced glutathione levels in liver of rats fed high sucrose high fat (HSHF) diet were normalized by concomitant administration of (+)-Catechin hydrate. Plasma non-enzymatic antioxidants viz. alpha-tocopherol, ascorbic acid and total thiols decrease were also significantly less in rats administered with (+)-Catechin hydrate concomitantly with HSHF diet. Thus the present results indicate that (+)-Catechin hydrate has antioxidant activity and is effective in reducing oxidative stress. The study is of clinical importance as oxidative stress is known to be the cause of many clinical manifestations viz. cancer, Parkinson's disease, atherosclerosis, heart failure, myocardial infarction and many other diseases.

Description

(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

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