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Catechin 7-xyloside

CAS# 42830-48-8

Catechin 7-xyloside

Catalog No. BCN5484----Order now to get a substantial discount!

Product Name & Size Price Stock
Catechin 7-xyloside: 5mg $828 In Stock
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Catechin 7-xyloside: 200mg Please Inquire Please Inquire
Catechin 7-xyloside: 500mg Please Inquire Please Inquire
Catechin 7-xyloside: 1000mg Please Inquire Please Inquire

Quality Control of Catechin 7-xyloside

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Chemical structure

Catechin 7-xyloside

3D structure

Chemical Properties of Catechin 7-xyloside

Cas No. 42830-48-8 SDF Download SDF
PubChem ID 73533 Appearance Powder
Formula C20H22O10 M.Wt 422.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3R,4S,5R)-2-[[(2R,3S)-2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-3,4-dihydro-2H-chromen-7-yl]oxy]oxane-3,4,5-triol
SMILES C1C(C(OC2=CC(=CC(=C21)O)OC3C(C(C(CO3)O)O)O)C4=CC(=C(C=C4)O)O)O
Standard InChIKey UQKKDJWFQBNZBJ-MLYGIHNMSA-N
Standard InChI InChI=1S/C20H22O10/c21-11-2-1-8(3-13(11)23)19-14(24)6-10-12(22)4-9(5-16(10)30-19)29-20-18(27)17(26)15(25)7-28-20/h1-5,14-15,17-27H,6-7H2/t14-,15+,17-,18+,19+,20-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Catechin 7-xyloside

The herbs of Spiraea hypericifolia L.

Biological Activity of Catechin 7-xyloside

Description1. Catechin-7-O-xyloside induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells, suggests that it has anti-cancer activity.

Catechin 7-xyloside Dilution Calculator

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Catechin 7-xyloside Molarity Calculator

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Preparing Stock Solutions of Catechin 7-xyloside

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3674 mL 11.8371 mL 23.6742 mL 47.3485 mL 59.1856 mL
5 mM 0.4735 mL 2.3674 mL 4.7348 mL 9.4697 mL 11.8371 mL
10 mM 0.2367 mL 1.1837 mL 2.3674 mL 4.7348 mL 5.9186 mL
50 mM 0.0473 mL 0.2367 mL 0.4735 mL 0.947 mL 1.1837 mL
100 mM 0.0237 mL 0.1184 mL 0.2367 mL 0.4735 mL 0.5919 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Catechin 7-xyloside

Catechin-7-O-xyloside induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.[Pubmed:24213951]

Oncol Rep. 2014 Jan;31(1):314-20.

The medicinal plant Ulmus davidiana var. japonica has significant potential as a cancer chemoprevention agent. Catechin-7-O-xyloside (C7Ox) was purified from ultrafine U. davidiana var. japonica ethanol extract. In the present study, we investigated the apoptotic effect of C7Ox in the non-small cell lung cancer (NSCLC) cell line H1299. C7Ox treatment induced cell death and decreased plasma membrane integrity, an event typical of apoptosis. C7Ox-induced apoptosis was associated with the proteolytic activation of caspase-6, cleavage of poly(ADP-ribose) polymerase (PARP) and loss of mitochondrial membrane potential. C7Ox also induced the endoplasmic reticulum (ER) stress-regulated pro-apoptotic transcription factor CHOP. The suppression of CHOP expression significantly decreased C7Ox-induced cell death, LDH leakage and caspase-6 activation. Antitumor effects, evaluated based on protracted tumor regression, were observed when nude-mice bearing H1299 xenografts were treated with C7Ox. C7Ox-induced tumor regression was accompanied by enhanced expression of CHOP mRNA. Our data suggest that C7Ox can trigger mitochondrial-mediated apoptosis, and that ER stress is critical for C7Ox-induced apoptosis in H1299 NSCLC cells.

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