KulactoneCAS# 22611-36-5 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 22611-36-5 | SDF | Download SDF |
| PubChem ID | 15560423 | Appearance | Powder |
| Formula | C30H44O3 | M.Wt | 452.67 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC(=CCCC1C2C(CC3(C2(CCC4C3=CCC5C4(CCC(=O)C5(C)C)C)C)C)OC1=O)C | ||
| Standard InChIKey | ZIVZDNPCRURPNL-QCWHEMHRSA-N | ||
| Standard InChI | InChI=1S/C30H44O3/c1-18(2)9-8-10-19-25-22(33-26(19)32)17-30(7)21-11-12-23-27(3,4)24(31)14-15-28(23,5)20(21)13-16-29(25,30)6/h9,11,19-20,22-23,25H,8,10,12-17H2,1-7H3/t19-,20+,22+,23+,25-,28-,29+,30-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Kulactone exhibits significant activity against Escherichia coli with minimum inhibitory concentration of 12.5 μg/mL, close to that of neomycin (6.25 μg/mL). 2. Kulactone inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line. |
| Targets | Antifection |
Kulactone Dilution Calculator
Kulactone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2091 mL | 11.0456 mL | 22.0911 mL | 44.1823 mL | 55.2279 mL |
| 5 mM | 0.4418 mL | 2.2091 mL | 4.4182 mL | 8.8365 mL | 11.0456 mL |
| 10 mM | 0.2209 mL | 1.1046 mL | 2.2091 mL | 4.4182 mL | 5.5228 mL |
| 50 mM | 0.0442 mL | 0.2209 mL | 0.4418 mL | 0.8836 mL | 1.1046 mL |
| 100 mM | 0.0221 mL | 0.1105 mL | 0.2209 mL | 0.4418 mL | 0.5523 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Antineoplastic agents. 489. Isolation and structures of meliastatins 1-5 and related euphane triterpenes from the tree Melia dubia.[Pubmed:12502333]
J Nat Prod. 2002 Dec;65(12):1886-91.
The bark of the giant neem tree Melia dubia was found to contain 11 euphane-type triterpenes. Five new compounds, meliastatins 1-5 (1-5), proved to inhibit growth of the P388 lymphocytic leukemia cell line (ED(50) 1.7-5.6 microg/mL). Four of the others, the previously known methyl kulonate (8), kulinone (9), 16-hydroxybutyrospermol (10), and Kulactone (11), were also found to inhibit (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line. In addition, two new euphane triterpenes were isolated and named dubione A (6) and dubione B (7). Structures for each of the 11 euphane triterpenes were established by spectral techniques that included HRMS and 2D NMR.
Antimicrobial compounds from root, stem bark and seeds of Melia volkensii.[Pubmed:26517430]
Nat Prod Res. 2016 Sep;30(17):1984-7.
Three compounds, toosendanin (1), Kulactone (2) and scopoletin (3), were isolated from either the root bark and/or the stem bark of Melia volkensii. Their structures were determined on the basis of spectroscopic data generated and by comparison with data from the literature. 1 and 2, isolated for the first time from M. volkensii, exhibited significant (p < 0.05) activity against Escherichia coli with minimum inhibitory concentration of 12.5 mug/mL, close to that of neomycin (6.25 mug/mL). The compounds also exhibited high activity against Aspergillus niger (MIC 6.25 mug/mL compared to 2.5 mug/mL for clotrimazole). Dichloromethane and methanol seed, hexane stem bark and methanol root bark extracts exhibited activities towards Escherichia coli, Staphylococcus aureus, Aspergillus niger and Plasmodium falciparum, respectively. Antimicrobial activity of the plant towards A. niger, P. falciparum and S. aureus is reported for the first time in the current work.
