Products with Hepatoprotective bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5171 | Geniposidic acid |
| Geniposidic acid is an effective anticancer and radioprotection agent, used to treat inflammation, jaundice and hepatic disorders. It has anti-atherosclerotic effects, can protect vascular endothelium and reverse plaque formation in an atherosclerotic model. Geniposidic acid has effects on the expression of MRP2 and BSEP in BRL-3A cells after FXR gene silencing mediated by si RNA. | |
| BCN5178 | Reynosin |
| 1. Reynosin has hepatoprotective effects, it can inhibit thioacetamide-induced apoptosis in primary hepatocytes and an in vivo mouse model. 2. Reynosin has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α-synuclein protein expression. 3. Reynosin exhibits a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM. 4. Reynosin has strong anti-mycobactericidal activity, with a minimal bactericidal concentration (MBC) of 128ug/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains and a minimal inhibitory concentration (MIC) of 64, 64, 128, 128 and 128ug/mL against the H37Rv, 104-2010, 63-2009, 366-2009 and 430-2010 Mtb strains, respectively. 5. Reynosin can inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophages. 6. Reynosin shows cytotoxicity against the KB cancer cell line (ATCC CCL17), with IC50 value of 2.7 microg/mL. 7. Reynosin shows moderate anti-inflammatory activity, it exhibits a concentration-related decrease in the levels of IL-1β, IL-6, TNF-α, PGE2, lipoxgenase-5, and COX-2. | |
| BCN5196 | Secoisolariciresinol |
| 1. Secoisolariciresinol and matairesinol are enterolignan precursors. 2. Secoisolariciresinol has antioxidant activity. 3. Secoisolariciresinol and isotaxiresinol prevent d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. 4. Secoisolariciresinol has estrogen-like activity, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes. 5. (-)-Secoisolariciresinol exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and β-oxidation of fatty acids. | |
| BCN5204 | Astilbin |
| Astilbin has insecticidal, antioxidant, antibacterial, and anti-inflammatory activities, it may act as an efficient therapeutic agent for arthritis like cyclosporine A but with less toxicity, its mechanism includes a selective suppression on lymphocyte functions via reducing MMP and NO production. Astilbin can exert an early renal protective role to diabetic nephropathy (DN), inhibit production of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF).Astilbin also alleviates contact hypersensitivity through a unique mechanism involving a negative cytokine regulation through stimulating IL-10, which is distinct from the immunosuppressant cyclosporin A. | |
| BCN5245 | Kaempferol 3-neohesperidoside |
| 1. Kaempferol 3-neohesperidoside has insulin-like properties in terms of glucose lowering. 2. Kaempferol 3-neohesperidoside stimulates glucose uptake in the rat soleus muscle via the PI3K and PKC pathways and, at least in part, independently of MEK pathways and the synthesis of new glucose transporters. 3. Kaempferol 3-neohesperidoside possesses not only a significant anticancer effect against HepG2 cells, but also an effective and a dose dependent hepatoprotective and antioxidant activities due to the presence of flavonoids content. | |
