Products with Hepatoprotective bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4686 | Hautriwaic acid |
| 1. Hautriwaic acid diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the inflammatory response. 2. Hautriwaic acid present in the methanolic extract and its ethyl acetate, and aqueous fractions may be responsible for this hepatoprotective activity of Dodonaea viscosa which was confirmed by in vivo experiments. 3. Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models. | |
| BCN4876 | Lucidone |
| 1. Lucidone has anti-inflammatory activity, the activity might be caused by the inhibition of iNOS and COX-2 expressions through downregulation of NF-kappaB and AP-1 binding. 2. Lucidone has hepatoprotective effect, it-mediated up-regulation of phase-II enzymes and HO-1 via Nrf-2 signaling pathway may provide a pivotal mechanism for its hepatoprotective action. 3. Lucidone may possess antioxidant and anti-inflammatory properties and may be useful for the prevention of free radical-induced skin damage. 4. Dietary intake of lucidone alleviates high fat diet-induced obesity in C57BL/6 mice and reveals the potential of lucidone as a nutraceutical to prevent obesity and consequent metabolic disorders. 5. Lucidone accelerates wound healing through the cooperation of keratinocyte/fibroblast/ ndothelial cell growth and migration and macrophage inflammation via PI3K/AKT, Wnt/β-catenin and NF-κB signaling cascade activation. 6. Lucidone suppresses hepatitis C virus replication by Nrf2-mediated heme oxygenase-1 induction, it could be a potential lead or supplement for the development of new anti-HCV agent in the future. | |
| BCN4889 | Tiliroside |
| 1. Tribuloside can improve behavior and BrdU immunoreactive cells of depression model rats and possess antidepressant effect. 2. Tribuloside exhibits antimycobacterial activity against the non-pathogenic Mycobacterium species Mycobacterium madagascariense and Mycobacterium indicus pranii, with a minimum inhibitory concentration (MIC) 5.0 mg/mL . 3. Tribuloside has 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity.4. Tiliroside possesses anti-inflammatory, antioxidant, anti-complement, anti-diabetic, anticarcinogenic and hepatoprotective activities. Tiliroside enhances fatty acid oxidation via the enhancement adiponectin signaling associated with the activation of both AMP-activated protein kinase and peroxisome proliferator-activated receptor α and ameliorates obesity-induced metabolic disorders. | |
| BCN4909 | Gentiopicroside |
| Gentiopicroside has been developed into a novel traditional Chinese drug named gentiopicroside injection, and it was approved for the treatment of acute jaundice and chronic active hepatitis by SFDA.Gentiopicroside has analgesic, smooth muscle relaxing, antibacterial, and free radical scavenging activities, it exerts anti-inflammatory effects on experimental acute colitis through attenuating the expression levels of TNF-α, IL-1β, IL-6, iNOS and COX-2. | |
| BCN4944 | 2,3-O-Isopropylidenyl euscaphic acid |
| 1. 2,3-O-Isopropylidenyl euscaphic acid shows good hepatoprotective effect,the EC50 value of 88.36±3.25 uM in Hep G2 cells. | |
