Products with Hepatoprotective bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3621 | Schisantherin C |
| 1. Schisantherin A, B, C, and D show good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. | |
| BCN3671 | Loureirin A |
| Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling. Loureirin A activates Wnt/-catenin pathway and promotes hair follicle stem cells (FSCs)-seeded tissue-engineered skin to repair skin wound.The molecular mechanism of Loureirin A and Wnt signaling pathway mediated anti- hepatic fibrosis and anti- angiogenesis may involve down- regulation the expression of Frizzled- 4,inhibiting the synthesis and secretion of α- SMA,TGF- β1and the proliferation of HSCs. | |
| BCN3693 | Mulberrofuran G |
| 1. Mulberrofuran G shows moderate activity, inhibits hepatitis B virus (HBV) DNA replication with the IC(50) value of 3.99 μM. | |
| BCN3706 | 14-Deoxyandrographolide |
| 1. 14-Deoxyandrographolide desensitizes hepatocytes to TNF-alpha-mediated apoptosis through the release of TNFRSF1A. 2. 14-Deoxyandrographolide has hepatoprotective activity, mediates activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS, may provide a promising approach in the prevention of liver diseases during chronic alcoholism. | |
| BCN3790 | Isokaempferide |
| 1. Isokaempferide shows anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. 2. Isokaempferide is used as a bronchodilator, can induce relaxation of guinea-pig isolated trachea. 3. The hydroxyflavones (luteolin, apigenin and isokaempferide) exert comparable antiproliferative activities against malignant and normal cells. 4. Isokaempferide shows strong inhibitory effect on TNF-alpha-induced liver cell death with the IC50 value of 22.8 microM, suggests that it has hepatoprotective activity. | |
